DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Imp and pcbp4

DIOPT Version :9

Sequence 1:NP_001245616.1 Gene:Imp / 32009 FlyBaseID:FBgn0285926 Length:638 Species:Drosophila melanogaster
Sequence 2:XP_009294752.1 Gene:pcbp4 / 406391 ZFINID:ZDB-GENE-040426-2122 Length:463 Species:Danio rerio


Alignment Length:521 Identity:119/521 - (22%)
Similarity:205/521 - (39%) Gaps:140/521 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   134 MPGP---------------GRQADFPLRILVQSEMVGAIIGRQGSTIRTITQQSRARVDVHRKEN 183
            :|||               |......||:|:..:.||:|||::|.|::.|.::|.||:::    :
Zfish     3 LPGPDSHVRMNCEQDFGDGGMNVTLTLRLLMHGKEVGSIIGKKGETVKRIREESSARINI----S 63

  Fly   184 VGSL-EKSITIYGNPENCTNACKRILEVMQQE--AISTNKGELSPECSEICLKILAHNNLIGRII 245
            .||. |:.|||.|..|....|...|...::::  |:..| |.::.: ..:.|:::...:..|.:|
Zfish    64 EGSCPERIITITGATECVFRAFTMITIKLEEDLAALVAN-GTVTSK-PPVTLRLVIPASQCGSLI 126

  Fly   246 GKSGNTIKRIMQDTDTKITVSSINDINSFNLERIITVKG---------------LIENMSR---- 291
            ||.|:.||.|.:.|..::.|:  .|:...:.||.:|:.|               ::|:..:    
Zfish   127 GKGGSKIKEIREKTGAQVQVA--GDLLPNSTERGVTISGSQDAIIQCVKLICTVILESPPKGATI 189

  Fly   292 -------------AENQI-----------------STKLRQSYENDLQAMAPQSLMFPGLHPMAM 326
                         |.||:                 ...|:|:|....|...|.|.: ..||.::|
Zfish   190 PYRPSPAPGAVLLAGNQVFETSEFASHPLFSVAQGGLDLQQAYTVQNQYGIPHSEL-AKLHQLSM 253

  Fly   327 MSTPGNGMVFNTSMPFPSCQSFAMSKTPASVVPPVFPNDLQETTYLYIPNNAVGAIIGTRGSHIR 391
            ....|           |..|:     |...|:|.:..:....:..|.|||:.:|:|||.:|:.|.
Zfish   254 QQGLG-----------PIAQA-----TATQVLPGIESSSQTASQELLIPNDLIGSIIGRQGTKIN 302

  Fly   392 SIMRFSNASLKIAPLDADKPLDQQTERKVTIVGTPEGQWKAQYMIFEKMREEGFMCGTDDVRLTV 456
            .|.:.|.|.:||.     ..||..::|.|||.|:|.....|||:|...:........:..:...|
Zfish   303 EIRQVSGAQIKIG-----SQLDSTSDRHVTITGSPISINLAQYLITSCLETAKSTAQSSSMSTPV 362

  Fly   457 ELLVASSQVGRIIGKGGQNVRELQRVTGSVIKLPEHALAPPS----------GGDEETPVHIIGL 511
            :|.::.:|.                             |||:          ||....|  |:|.
Zfish   363 DLNMSFTQT-----------------------------APPASSSAAALAAMGGLPHAP--ILGA 396

  Fly   512 FYSVQ-SAQRRIRAM-MLSTNPPPITKKQKAAKEQLQQQQQSLAGAASSGSQQQQPQSPSQQQAL 574
            .|::. |:...|::: .|:.:.|..|....||.........|||...:..|.....:.|.:|:..
Zfish   397 PYTLPLSSLLGIKSVPFLALSAPAATAAAAAAAAAAAPAHGSLASYTAKISSANGIKKPERQKFA 461

  Fly   575 P 575
            |
Zfish   462 P 462

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ImpNP_001245616.1 RRM <37..>146 CDD:223796 4/26 (15%)
RRM2_VICKZ 42..118 CDD:240805
KH-I 145..208 CDD:238053 23/63 (37%)
KH-I 232..296 CDD:238053 19/95 (20%)
KH-I 369..436 CDD:238053 26/66 (39%)
KH-I 455..522 CDD:238053 13/77 (17%)
pcbp4XP_009294752.1 PCBP_like_KH 28..89 CDD:239089 23/64 (36%)
PCBP_like_KH 112..176 CDD:239089 16/65 (25%)
KH-I 280..342 CDD:238053 26/66 (39%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170574652
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.840

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