DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Imp and Pcbp2

DIOPT Version :9

Sequence 1:	NP_001245616.1	Gene:	Imp / 32009	FlyBaseID:	FBgn0285926	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	XP_017450492.1	Gene:	Pcbp2 / 363005	RGDID:	1309626	Length:	471	Species:	Rattus norvegicus

Alignment Length:	546	Identity:	109/546 - (19%)
Similarity:	192/546 - (35%)	Gaps:	205/546 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 GRQADFPLRILVQSEMVGAIIGRQGSTIRTITQQSRARVDVHRKENVGSL-EKSITIYGNPENCT 201
            |......:|:|:..:.||:|||::|.:::.:.::|.||:::    :.|:. |:.||:.|......
  Rat     9 GLNVTLTIRLLMHGKEVGSIIGKKGESVKKMREESGARINI----SEGNCPERIITLAGPTNAIF 69

  Fly   202 NACKRILEVMQQEAISTNKGELSPECSEICLKILAHNNLIGRIIGKSGNTIKRIMQDTDTKITVS 266
            .|...|::.::::..|:.....:.....:.|:::...:..|.:|||.|..||.|.:.|..::.|:
  Rat    70 KAFAMIIDKLEEDISSSMTNSTAASRPPVTLRLVVPASQCGSLIGKGGCKIKEIRESTGAQVQVA 134

  Fly   267 SINDINSFNLERIITVKGLIENMSRAENQISTKLRQSYE-------------------------N 306
              .|:...:.||.||:.|:.:::.....||...:.::..                         .
  Rat   135 --GDMLPNSTERAITIAGIPQSIIECVKQICVVMLETLSQSPPKGVTIPYRPKPSSSPVIFAGGQ 197

  Fly   307 DLQAMAPQSLMFPGLHPMAMMSTPGNGMVFNTSMPFPSCQSFAMSKTPASVVPPV---------- 361
            |..:....|..||  |     :||  .|..|..:..|..:::.:....|...|.:
  Rat   198 DRYSTGSDSASFP--H-----TTP--SMCLNPDLEGPPLEAYTIQGQYAIPQPDLTKLHQLAMQQ 253

  Fly   362 --FP--------------------------NDLQETTY-LYIPNNAVGAIIGTRGSHIRSIMRFS 397
              ||                          ...|.|:: |.|||:.:|.|||.:|:.|..|.:.|
  Rat   254 SHFPMTHGNTGFSGIESSSPEVKGYWAGLDASAQTTSHELTIPNDLIGCIIGRQGAKINEIRQMS 318

  Fly   398 NASLKIAPLDADKPLDQQTERKVTIVGTPEGQWKAQYMIFEKMREEGFMCGTDDVRLTVELLVAS 462
            .|.:|||     .|::..|:|:|||.|:......|||:|                .:::|....|
  Rat   319 GAQIKIA-----NPVEGSTDRQVTITGSAASISLAQYLI----------------NVSLENAKPS 362

  Fly   463 SQVGRIIGKGGQNVRELQRVTGSVIKLPEHALAPPSGGDEETPVHIIGLFYSVQSAQRRIRAMML 527
            ||                   .:.:.:|:|                                  |
  Rat   363 SQ-------------------AASVTIPDH----------------------------------L 374

  Fly   528 STNPPPITKKQKAAKEQLQQQQQSLAGAASSGSQQQQPQSPSQQQALPPQLHHQPVSSASSSSTP 592
            |.|                               ..||.:||              ||:|||:|.
  Rat   375 SIN-------------------------------LSQPSTPS--------------SSSSSSTTT 394

  Fly   593 PAHHQQQASTAATSHQLQQQQPSPPP 618
            |:     .:||.|| ......|:|.|
  Rat   395 PS-----LATAGTS-DAPSSLPNPLP 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Imp	NP_001245616.1	RRM	<37..>146	CDD:223796	1/7 (14%)
		RRM2_VICKZ	42..118	CDD:240805
		KH-I	145..208	CDD:238053	17/63 (27%)
		KH-I	232..296	CDD:238053	17/63 (27%)
		KH-I	369..436	CDD:238053	27/67 (40%)
		KH-I	455..522	CDD:238053	6/66 (9%)
Pcbp2	XP_017450492.1	KH-I_PCBP1_2_rpt1	13..82	CDD:411943	18/72 (25%)
		KH-I_PCBP1_2_rpt2	92..169	CDD:411946	19/78 (24%)
		KH-I_PCBP1_2_rpt3	285..360	CDD:411949	30/95 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335342
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840