Protein Alignment Imp and Igf2bp3

DIOPT Version :9

• Sequence 1: NP_001245616.1
• Gene: Imp / 32009
• FlyBaseID: FBgn0285926
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: XP_038963480.1
• Gene: Igf2bp3 / 312320
• RGDID: 1306512
• Length: 628
• Species: Rattus norvegicus
• Alignment Length: 595
• Identity: 216/595 - (36%)
• Similarity: 314/595 - (52%)
• Gaps: 130/595 - (21%)

  Fly    43 KILISGIPMQTRFEDIEPLLKPYGIVKQCEAISSKDQNTQTVHITFENPEQAQRAAVGLNGVEFE 107
            |:.|..||...::|.::.||..||:|:.||.::: |..|..|::|:.:.:||::|...|||.:.|
  Rat    82 KLQIRNIPPHLQWEVLDSLLVQYGVVESCEQVNT-DSETAVVNVTYSSKDQARQALDKLNGFQLE 145

  Fly   108 GSKLH---------AEQLDKNQRRSQRNQRNPYPGMPGPGRQ-----------ADFPLRILVQSE 152
            ...|.         |:|....|.|.:|.     ||..|..||           .|.|||:||.::
  Rat   146 NFTLKVAYIPDETAAQQSPSPQLRGRRG-----PGQRGSSRQTSPGSVSKQKPCDLPLRLLVPTQ 205

  Fly   153 MVGAIIGRQGSTIRTITQQSRARVDVHRKENVGSLEKSITIYGNPENCTNACKRILEVMQQEAIS 217
            .||||||::|:|||.||:|:::::|||||||.|:.||||||...||..:.|||.|||:|.:||..
  Rat   206 FVGAIIGKEGATIRNITKQTQSKIDVHRKENTGAAEKSITILSTPEGTSAACKSILEIMHKEAQD 270

  Fly   218 TNKGELSPECSEICLKILAHNNLIGRIIGKSGNTIKRIMQDTDTKITVSSINDINSFNLERIITV 282
            ....|      ||.||||||||.:||:|||.|..:|:|.||||||||:|.:.::..:|.||.|||
  Rat   271 IKFTE------EIPLKILAHNNFVGRLIGKEGRNLKKIEQDTDTKITISPLQELTLYNPERTITV 329

  Fly   283 KGLIENMSRAENQISTKLRQSYENDLQAM------------------------------------ 311
            ||.:|..::||.:|..|:|:|||||:.:|
  Rat   330 KGNVETCAKAEEEIMKKIRESYENDIASMNGLYHPLLASVSTGCTWRAAIQATGTSIHMYLRDKY 394

  Fly   312 -----------AP--QSLMFPGLHPMAM-MSTPGNGMVFNTSMPFPSCQSFAMSKTPASVVPPV- 361
                       .|  |:.:.|||:..|: :..|.:||...||.|            |:::.||.
  Rat   395 TDTVFPRGSCILPKLQAHLIPGLNLNALGLFPPTSGMPPPTSGP------------PSAMTPPYP 447

  Fly   362 -FPNDLQETTYLYIPNNAVGAIIGTRGSHIRSIMRFSNASLKIAPLDADKPLDQQTERKVTIVGT 425
             |.....||.:|:||..:||||||.:|.||:.:.||:.||:||||.:|.   |.:. |.|.|.|.
  Rat   448 QFEQSETETVHLFIPALSVGAIIGKQGQHIKQLSRFAGASIKIAPAEAP---DAKV-RMVIITGP 508

  Fly   426 PEGQWKAQYMIFEKMREEGFMCGTDDVRLTVELLVASSQVGRIIGKGGQNVRELQRVTGSVIKLP 490
            ||.|:|||..|:.|::||.|:...::|:|...:.|.|...||:|||||:.|.|||.::.:.:.:|
  Rat   509 PEAQFKAQGRIYGKIKEENFVSPKEEVKLEAHIRVPSFAAGRVIGKGGKTVNELQNLSSAEVVVP 573

  Fly   491 EHALAPPSGGDEETP-------VHIIGLFYSVQSAQRRIRAMMLSTNPPPITKKQKAAKEQLQQQ 548
            .          ::||       |.|.|.||:.|.|||:|:.::...             :|.|||
  Rat   574 R----------DQTPDENDQVVVKITGHFYACQVAQRKIQEILTQV-------------KQHQQQ 615

  Fly   549 QQSLAGAASS 558
            :...:||..|
  Rat   616 KALQSGAPQS 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Imp	NP_001245616.1	RRM	<37..>146	CDD:223796	36/122 (30%)
		RRM2_VICKZ	42..118	CDD:240805	26/83 (31%)
		KH-I	145..208	CDD:238053	36/62 (58%)
		KH-I	232..296	CDD:238053	36/63 (57%)
		KH-I	369..436	CDD:238053	33/66 (50%)
		KH-I	455..522	CDD:238053	25/73 (34%)
Igf2bp3	XP_038963480.1	RRM_SF	1..77	CDD:418427
		RRM2_IGF2BP3	81..156	CDD:410039	24/74 (32%)
		KH-I_IGF2BP3_rpt1	197..272	CDD:411920	43/74 (58%)
		KH-I	275..359	CDD:412160	47/89 (53%)
		KH-I_IGF2BP3_rpt3	451..528	CDD:411926	38/80 (48%)
		KH-I_IGF2BP1_rpt4	536..611	CDD:411927	27/97 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335348
Domainoid	1	1.000	86	1.000	Domainoid score	I7895
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2109
OMA	1	1.010	-	-		QHG45563
OrthoDB	1	1.010	-	-		D428942at33208
OrthoFinder	1	1.000	-	-		FOG0001972
OrthoInspector	1	1.000	-	-		otm44382
orthoMCL	1	0.900	-	-		OOG6_103496
Panther	1	1.100	-	-	LDO	PTHR10288
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X348
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.910