DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Imp and Pcbp3

DIOPT Version :9

Sequence 1:	NP_001245616.1	Gene:	Imp / 32009	FlyBaseID:	FBgn0285926	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	XP_038954494.1	Gene:	Pcbp3 / 294336	RGDID:	1307430	Length:	402	Species:	Rattus norvegicus

Alignment Length:	371	Identity:	92/371 - (24%)
Similarity:	159/371 - (42%)	Gaps:	81/371 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 GRQADFPLRILVQSEMVGAIIGRQGSTIRTITQQSRARVDVHRKENVGSL-EKSITIYGNPENCT 201
            |......:|:|:..:.||:|||::|.|::.:.::|.||:::    :.|:. |:.:||.|..:...
  Rat    41 GLNVTLTIRLLMHGKEVGSIIGKKGETVKKMREESGARINI----SEGNCPERIVTITGPTDAIF 101

  Fly   202 NACKRILEVMQQEAISTNKGELSPECSE--ICLKILAHNNLIGRIIGKSGNTIKRIMQDTDTKIT 264
            .|...|....:::.|  |....||..|:  :.|:::...:..|.:|||.|:.||.|.:.|..::.
  Rat   102 KAFAMIAYKFEEDII--NSMSNSPATSKPPVTLRLVVPASQCGSLIGKGGSKIKEIRESTGAQVQ 164

  Fly   265 VSSINDINSFNLERIITVKGLIENMSRAENQISTKLRQS--------YENDLQAMAPQSLMFPG- 320
            |:  .|:...:.||.:|:.|..:.:.:...||...:.:|        |.   ...|...::|.|
  Rat   165 VA--GDMLPNSTERAVTISGTPDAIIQCVKQICVVMLESPPKGATIPYR---PKPASTPVIFAGG 224

  Fly   321 ---LHPMAMMST-----------PGNGMVFNTSMPFP--SCQSF----------AMSKT---PAS 356
               ..|:|..:.           |...:....::|.|  ||.|:          ||.:|   |..
  Rat   225 QVRADPLAASTANLSLLLQHPPLPAYTIQGQYAIPHPDLSCPSYPQQLTKLHQLAMQQTPFPPLG 289

  Fly   357 VVPPVFPNDL------------------------QETTYLYIPNNAVGAIIGTRGSHIRSIMRFS 397
            ...|.||.:.                        ..|..|.|||:.:|.|||.:|:.|..|.:.|
  Rat   290 QTNPAFPGEKLPLHSSEEAQNLMGQSSGLDASPPASTHELTIPNDLIGCIIGRQGTKINEIRQMS 354

  Fly   398 NASLKIAPLDADKPLDQQTERKVTIVGTPEGQWKAQYMIFEKMREE 443
            .|.:|||     ...:..:||::||.|||.....|||:|..::..|
  Rat   355 GAQIKIA-----NATEGSSERQITITGTPANISLAQYLINARLTSE 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Imp	NP_001245616.1	RRM	<37..>146	CDD:223796	1/7 (14%)
		RRM2_VICKZ	42..118	CDD:240805
		KH-I	145..208	CDD:238053	18/63 (29%)
		KH-I	232..296	CDD:238053	16/63 (25%)
		KH-I	369..436	CDD:238053	27/66 (41%)
		KH-I	455..522	CDD:238053
Pcbp3	XP_038954494.1	KH-I_PCBP3_rpt1	38..114	CDD:411944	20/76 (26%)
		KH-I_PCBP3_rpt2	125..203	CDD:411947	20/79 (25%)
		KH-I_PCBP3_rpt3	317..391	CDD:411950	28/78 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335344
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840