Protein Alignment Imp and Igf2bp1

DIOPT Version :10

• Sequence 1: NP_001245616.1
• Gene: Imp / 32009
• FlyBaseID: FBgn0285926
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: NP_034081.1
• Gene: Igf2bp1 / 140486
• MGIID: 1890357
• Length: 577
• Species: Mus musculus
• Alignment Length: 550
• Identity: 216/550 - (39%)
• Similarity: 321/550 - (58%)
• Gaps: 64/550 - (11%)

  Fly    28 RQQLEGAGTSSVTTSKILISGIPMQTRFEDIEPLLKPYGIVKQCEAISSKDQNTQTVHITFENPE 92
            |.::|.:......:.||.|..||.|.|:|.::.||..||.|:.||.::::.: |..|::|:.|.|
Mouse    67 RLEIEHSVPKKQRSRKIQIRNIPPQLRWEVLDSLLAQYGTVENCEQVNTESE-TAVVNVTYSNRE 130

  Fly    93 QAQRAAVGLNGVEFEGSKLHAEQLDKNQ--------------RRSQRNQRNPY-PGMPGPGRQAD 142
            |.::|.:.|||.:.|...|....:...|              .|.|..|.:|. .|.|...:..|
Mouse   131 QTRQAIMKLNGHQLENHALKVSYIPDEQITQGPENGRRGGFGSRGQPRQGSPVAAGAPAKQQPVD 195

  Fly   143 FPLRILVQSEMVGAIIGRQGSTIRTITQQSRARVDVHRKENVGSLEKSITIYGNPENCTNACKRI 207
            .|||:||.::.||||||::|:|||.||:|:::::|||||||.|:.||:|:::..||.|::|||.|
Mouse   196 IPLRLLVPTQYVGAIIGKEGATIRNITKQTQSKIDVHRKENAGAAEKAISVHSTPEGCSSACKMI 260

  Fly   208 LEVMQQEAISTNKGELSPECSEICLKILAHNNLIGRIIGKSGNTIKRIMQDTDTKITVSSINDIN 272
            ||:|.:||..|...:      |:.||||||||.:||:|||.|..:|::.|||:||||:||:.|:.
Mouse   261 LEIMHKEAKDTKTAD------EVPLKILAHNNFVGRLIGKEGRNLKKVEQDTETKITISSLQDLT 319

  Fly   273 SFNLERIITVKGLIENMSRAENQISTKLRQSYENDLQAMAPQSLMFPGLHPMAMMSTPGNGMVFN 337
            .:|.||.|||||.|||..|||.:|..|:|::||||:.||:.||.:.|||:..|:...|.:    :
Mouse   320 LYNPERTITVKGAIENCCRAEQEIMKKVREAYENDVAAMSLQSHLIPGLNLAAVGLFPAS----S 380

  Fly   338 TSMPFPSCQSFAMSKTPASVVPPVFPNDLQETTYLYIPNNAVGAIIGTRGSHIRSIMRFSNASLK 402
            :::|.|     ..|.|.|:..........||...::||..|||||||.:|.||:.:.||::||:|
Mouse   381 SAVPPP-----PSSVTGAAPYSSFMQAPEQEMVQVFIPAQAVGAIIGKKGQHIKQLSRFASASIK 440

  Fly   403 IAPLDADKPLDQQTERKVTIVGTPEGQWKAQYMIFEKMREEGFMCGTDDVRLTVELLVASSQVGR 467
            |||.:..   |.:. |.|.|.|.||.|:|||..|:.|::||.|....::|:|...:.|.:|..||
Mouse   441 IAPPETP---DSKV-RMVVITGPPEAQFKAQGRIYGKLKEENFFGPKEEVKLETHIRVPASAAGR 501

  Fly   468 IIGKGGQNVRELQRVTGSVIKLPEHALAPPSGGDEETP-------VHIIGLFYSVQSAQRRIRAM 525
            :|||||:.|.|||.:|.:.:.:|.          ::||       |.|||.||:.|.|||:||.:
Mouse   502 VIGKGGKTVNELQNLTAAEVVVPR----------DQTPDENDQVIVKIIGHFYASQMAQRKIRDI 556

  Fly   526 MLSTNPPPITKKQKAAKEQLQQQQQSLAGA 555
            :..            .|:|.|:.|.:||.|
Mouse   557 LAQ------------VKQQHQKGQSNLAQA 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Imp	NP_001245616.1	RRM2_VICKZ	42..118	CDD:409794	27/75 (36%)
		KH-I_IGF2BP_rpt1	144..211	CDD:411828	38/66 (58%)
		KH-I_IGF2BP_rpt2	231..302	CDD:411829	41/70 (59%)
		KH-I_IGF2BP_rpt3	368..437	CDD:411830	32/68 (47%)
		KH-I_IGF2BP_rpt4	455..523	CDD:411831	27/74 (36%)
Igf2bp1	NP_034081.1	RRM1_IGF2BP1	1..77	CDD:241069	2/9 (22%)
		RRM2_IGF2BP1	81..156	CDD:410037	27/75 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	156..190		7/33 (21%)
		KH-I_IGF2BP1_rpt1	197..272	CDD:411918	41/74 (55%)
		KH-I_IGF2BP1_rpt2	273..369	CDD:411921	53/101 (52%)
		Sufficient for nuclear export. /evidence=ECO:0000250	312..323		3/10 (30%)
		KH-I_IGF2BP1_rpt3	404..479	CDD:411924	37/78 (47%)
		Sufficient for nuclear export. /evidence=ECO:0000250	485..495		2/9 (22%)
		KH-I_IGF2BP1_rpt4	487..562	CDD:411927	30/96 (31%)