Protein Alignment Ant2 and SLC25A4

DIOPT Version :10

• Sequence 1: NP_511110.1
• Gene: Ant2 / 32008
• FlyBaseID: FBgn0025111
• Length: 307
• Species: Drosophila melanogaster
• Sequence 2: NP_001142.2
• Gene: SLC25A4 / 291
• HGNCID: 10990
• Length: 298
• Species: Homo sapiens
• Alignment Length: 307
• Identity: 220/307 - (71%)
• Similarity: 252/307 - (82%)
• Gaps: 11/307 - (3%)

  Fly     1 MGDEGGGGGHGKGDLKSFLMDFMMGGVSAAIAKTAVAPIERVKLILQVQEVSKQIAADQRYKGIV 65
            |||...          |||.||:.|||:||::||||||||||||:||||..||||:|:::||||:
Human     1 MGDHAW----------SFLKDFLAGGVAAAVSKTAVAPIERVKLLLQVQHASKQISAEKQYKGII 55

  Fly    66 DCFIRIPKEQGFSSFWRGNLANVIRYFPTQALNFAFKDVYKSVFLGGVDKHKQFWRHFAGNLASG 130
            ||.:||||||||.|||||||||||||||||||||||||.||.:||||||:||||||:||||||||
Human    56 DCVVRIPKEQGFLSFWRGNLANVIRYFPTQALNFAFKDKYKQLFLGGVDRHKQFWRYFAGNLASG 120

  Fly   131 GAAGATSLCFVYPLDFARTRLAADVGKG-GNREFNGLIDCLMKVIKSDGPIGLYRGFIVSVQGIV 194
            |||||||||||||||||||||||||||| ..|||:||.||::|:.||||..|||:||.||||||:
Human   121 GAAGATSLCFVYPLDFARTRLAADVGKGAAQREFHGLGDCIIKIFKSDGLRGLYQGFNVSVQGII 185

  Fly   195 IYRAAYFGFYDTCRDFLPNPKSTPFYVSWAIAQVVTTVAGIASYPFDTVRRRMMMQSGLKKSEMV 259
            ||||||||.|||.:..||:||:...:|||.|||.||.|||:.||||||||||||||||.|.::::
Human   186 IYRAAYFGVYDTAKGMLPDPKNVHIFVSWMIAQSVTAVAGLVSYPFDTVRRRMMMQSGRKGADIM 250

  Fly   260 YKNTAHCWLVIAKQEGIGAFFKGALSNIIRGTGGALVLALYDEMKKY 306
            |..|..||..|||.||..||||||.||::||.|||.||.||||:|||
Human   251 YTGTVDCWRKIAKDEGAKAFFKGAWSNVLRGMGGAFVLVLYDEIKKY 297

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ant2	NP_511110.1	PTZ00169	15..305	CDD:240302	214/290 (74%)
SLC25A4	NP_001142.2	Solcar 1	6..98		72/101 (71%)
		PTZ00169	7..298	CDD:240302	217/291 (75%)
		Solcar 2	111..201		71/89 (80%)
		Solcar 3	212..297		57/84 (68%)
		Important for transport activity. /evidence=ECO:0000269|PubMed:27693233	235..240		4/4 (100%)
		Nucleotide carrier signature motif. /evidence=ECO:0000250|UniProtKB:P02722	235..240		4/4 (100%)