DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stx and MIDN

DIOPT Version :9

Sequence 1:	NP_001259426.1	Gene:	stx / 32005	FlyBaseID:	FBgn0052676	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	XP_024307521.1	Gene:	MIDN / 90007	HGNCID:	16298	Length:	631	Species:	Homo sapiens

Alignment Length:	1028	Identity:	216/1028 - (21%)
Similarity:	308/1028 - (29%)	Gaps:	510/1028 - (49%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 AVVASPMTINLNISTTTGGNFGVSVEPHISVESLKKIIAKKLKVAKDRICLLHREKELQDGTLRD 125
            |..|:||  :|.|.:|||..:.::|.|..:||.|:|.::::|||.|:|:.|||::..|..|.|::
Human    25 AAEAAPM--SLAIHSTTGTRYDLAVPPDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSGKLQE 87

  Fly   126 HNLMDGSKIILIPNVETGLLAQ--RPENTVMQALESLNDA------------------------- 163
            ..:.||||:.|:|.||.||::|  |||.:||||||||.:.
Human    88 FGVGDGSKLTLVPTVEAGLMSQASRPEQSVMQALESLTETQPPAAPGPGRAGGGGFRKYRFILFK 152

  Fly   164 ------------------QVNDFLSGKTPLNLSMRLGDHMMLIQLQLSTVNPAGGGAATVAPVAG 210
                              ||:|||||::||.|::|:|||||.:||||         ||..||
Human   153 RPWHRQGPQSPERGGERPQVSDFLSGRSPLTLALRVGDHMMFVQLQL---------AAQHAP--- 205

  Fly   211 GASGSSINAAASTTSTVPVMPAGTGCSGANSTSLSSSAVLAAAAAGVGGSTGTSGSGTSSSSSST 275
                                             |....|||||||      ..:..|..|.:|..
Human   206 ---------------------------------LQHRHVLAAAAA------AAAARGDPSIASPV 231

  Fly   276 SSSSSSSSSSSRTRSSGQRSSGRIGHGHVHSHQHPSLHAANWHGFSHGHGHGHSHGNGHGHHHHH 340
            ||.....||::|
Human   232 SSPCRPVSSAAR----------------------------------------------------- 243

  Fly   341 HHHHHHHHHHHNASAVAAGSGGGMSSLRKMYGDLPSSSGASGSAPATGTGQSQSSSTLNGPDLTK 405
                                             :|
Human   244 ---------------------------------VP------------------------------ 245

  Fly   406 LLIKGGIQNIVNSFALKDAGANARPVANGGSGSSPGKPVLEQSPIKSLSNLVSSPIKMTTIKNIP 470
                                    ||....|.:||                  |||...:.::
Human   246 ------------------------PVPTSPSPASP------------------SPITAGSFRS-- 266

  Fly   471 LPTTAATSSSSSCNCSSAAPSSSSSTSSGACATGGCQQDPIAAKLTSCLCTRLPTPSVAPPVATL 535
              ..|:|:.....:||   |::|||.|.||..|.                    ||.
Human   267 --HAASTTCPEQMDCS---PTASSSASPGASTTS--------------------TPG-------- 298

  Fly   536 VAPAPVARSGSTSSPSKCPESSCSGANAGFAARSTLAGTRVTFSGNSMLHKTGNNRITRTKHRHY 600
            .:|||.:|     .|....||..:.|...|:.         ||||..
Human   299 ASPAPRSR-----KPGAVIESFVNHAPGVFSG---------TFSGRC------------------ 331

  Fly   601 HGQGHGHGHGNGHSSSSSSSSS-------SSSSHFFNHACAGNQPSVNAAAFATSSSSSSSSPSS 658
                        ||:..||..|       |:|:|...|........|..........|.:.:|
Human   332 ------------HSTCVSSRVSRDPVHLGSTSTHRRLHIFWAYTGCVRLLTSHVPQESPTHTP-- 382

  Fly   659 SSSSPSKRRKLEQGMGAGAVG--ATAATATAAATVALPASTSATTAEPDDSLLGVSDTRTLAEAS 721
                         |...||.|  |.|...........|:.|||..:.|...|
Human   383 -------------GPARGAAGHQAPAYWGRVPLPPRGPSCTSAHMSTPLPEL------------- 421

  Fly   722 RNLTQTLRKLSKEVFTNKIDLSGAGVVSSGRSSSSGATSSGAASGEEAPRKSGSGAVIESMKNHG 786
                     :|...:|..:|:...                 |.:|...|...
Human   422 ---------MSSHPWTPVLDMRDC-----------------ARAGHSRPPLP------------- 447

  Fly   787 KGIYSGTFSGTLNPALQDRFGRPKRDISTVIHILNDLLSATPQYGRGARISFEAPTTGSVSGSGS 851
                    :|||:|..||..|||:|||.|::.|||||||||
Human   448 --------AGTLHPNCQDSSGRPRRDIGTILQILNDLLSAT------------------------ 480

  Fly   852 GSGSSGSSSTTSSGSGLHHGSRSKMYSSKHHNCAKCNSRAQQQQQQSATLASGSGGSCSFRDCPS 916
                                   :.|.....:.|:....||                ||    |:
Human   481 -----------------------RHYQGMPPSLAQLRCHAQ----------------CS----PA 502

  Fly   917 YHSSSAATKASTSSKSSSHSCCQTAEAPSS--MTSQSNGCTCRYRRDDGQGEREREHTCQKCTVE 979
            ..:...|.:.:        ||.:...|||:  :..||....|:     ..|:|.|         :
Human   503 SPAPDLAPRTT--------SCEKLTAAPSASLLQGQSQIRMCK-----PPGDRLR---------Q 545

  Fly   980 LANMKTRSKMDQLRLVMQQHKQKREARKLKSGPYATAASASAADSLSSIAAGG 1032
            ..|..||.|:::|:|::||.:.:|:||:...|||..:.|..|..|.||.:.||
Human   546 TENRATRCKVERLQLLLQQKRLRRKARRDARGPYHWSPSRKAGRSDSSSSGGG 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stx	NP_001259426.1	UBQ	66..145	CDD:320785	33/78 (42%)
MIDN	XP_024307521.1	midnolin_N	30..107	CDD:176399	33/78 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148298
Domainoid	1	1.000	56	1.000	Domainoid score	I11075
eggNOG	1	0.900	-	-		E1_28KXC
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	191	1.000	Inparanoid score	I3880
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1159802at2759
OrthoFinder	1	1.000	-	-		FOG0009367
OrthoInspector	1	1.000	-	-		oto89082
orthoMCL	1	0.900	-	-		OOG6_110744
Panther	1	1.100	-	-	LDO	PTHR23010
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5240
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.880