Protein Alignment stx and Midn

DIOPT Version :10

• Sequence 1: NP_572648.1
• Gene: stx / 32005
• FlyBaseID: FBgn0052676
• Length: 1122
• Species: Drosophila melanogaster
• Sequence 2: NP_067540.1
• Gene: Midn / 59090
• MGIID: 1890222
• Length: 508
• Species: Mus musculus
• Alignment Length: 1024
• Identity: 195/1024 - (19%)
• Similarity: 270/1024 - (26%)
• Gaps: 616/1024 - (60%)

  Fly    55 LATTTSAVVASPMTINLNISTTTGGNFGVSVEPHISVESLKKIIAKKLKVAKDRICLLHREKELQ 119
            |.|.|.:  |:||  :|.|.:|||..:.:||....:||.|:|.::::|||.|:|:.|||::..|.
Mouse    22 LNTATES--AAPM--SLAIHSTTGTRYDLSVPHDETVEGLRKRLSQRLKVPKERLALLHKDTRLS 82

  Fly   120 DGTLRDHNLMDGSKIILIPNVETGLLAQ--RPENTVMQALESLNDA------------------- 163
            .|.|::..:.||||:.|:|.||.||::|  |||.:||||||||.:.
Mouse    83 SGKLQEFGVGDGSKLTLVPTVEAGLMSQASRPEQSVMQALESLTETQPPATPGPGRAAGGGFRKY 147

  Fly   164 ------------------------QVNDFLSGKTPLNLSMRLGDHMMLIQLQLSTVNPAGGGAAT 204
                                    ||:|||||::||.|::|:|||||.:||||         ||.
Mouse   148 RLILFKRPWHRQGPQSPERGGERPQVSDFLSGRSPLTLALRVGDHMMFVQLQL---------AAQ 203

  Fly   205 VAPVAGGASGSSINAAASTTSTVPVMPAGTGCSGANSTSLSSSAVLAAAAAGVGGSTGTSGSGTS 269
            .||                                    |....|||||||
Mouse   204 HAP------------------------------------LQHRHVLAAAAA-------------- 218

  Fly   270 SSSSSTSSSSSSSSSSSRTRSSGQRSSGRIGHGHVHSHQHPSLHAANWHGFSHGHGHGHSHGNGH 334
                                                                             
Mouse   219 ----------------------------------------------------------------- 218

  Fly   335 GHHHHHHHHHHHHHHHHNASAVAAGSGGGMSSLRKMYGDLPSSSGASGSAPATGTGQSQSSSTLN 399
                                  ||.:..|.||:
Mouse   219 ----------------------AAAAARGDSSV-------------------------------- 229

  Fly   400 GPDLTKLLIKGGIQNIVNSFALKDAGANARPVANGGSGSSPGKPVLEQSPIKSLSNLVSSPIKMT 464
                                        |.||      |||.:||...:.:..:|:..|||:.
Mouse   230 ----------------------------ATPV------SSPCRPVSSAARVPPVSSSPSSPVS-- 258

  Fly   465 TIKNIPLPTTAATSSSSSCNCSSAAPSSSSSTSSGACATGGCQQDPIAAKLTSCLCTRLPTPSVA 529
                 |.|.||.:..|
Mouse   259 -----PSPVTAGSFRS------------------------------------------------- 269

  Fly   530 PPVATLVAPAPVARSGSTSSPSKCPES-SCSGANAGFAARSTLAGTRVTFSGNSMLHKTGNNRIT 593
                         .:.||:    |||. .||
Mouse   270 -------------HAASTT----CPEQMDCS---------------------------------- 283

  Fly   594 RTKHRHYHGQGHGHGHGNGHSSSSSSSSSSSSSHFFNHACAGNQPSVNAAAFATSSSSSSSSPSS 658
                                                                ..:||||:|:|.|
Mouse   284 ----------------------------------------------------PPASSSSTSTPGS 296

  Fly   659 SSSSPSKRRKLEQGMGAGAVGATAATATAAATVALPASTSATTAEPDDSLLGVSDTRTLAEASRN 723
            |.:
Mouse   297 SPT-------------------------------------------------------------- 299

  Fly   724 LTQTLRKLSKEVFTNKIDLSGAGVVSSGRSSSSGATSSGAASGEEAPRKSGSGAVIESMKNHGKG 788
                                                          ||....||||||..||..|
Mouse   300 ----------------------------------------------PRSRKPGAVIESFVNHAPG 318

  Fly   789 IYSGTFSGTLNPALQDRFGRPKRDISTVIHILNDLLSATPQYGRGARISFEAPTTGSVSGSGSGS 853
            ::||||||||:|..||..|||:|||.|::.|||||||||..|
Mouse   319 VFSGTFSGTLHPNCQDSSGRPRRDIGTILQILNDLLSATRHY----------------------- 360

  Fly   854 GSSGSSSTTSSGSGLHHGSRSKMYSSKHHNCAKCNSRAQQQQQQSATLASGSGGSCSFRDCPSYH 918
                            .|....:...:.|  |:|
Mouse   361 ----------------QGMPPSLTQLRCH--AQC------------------------------- 376

  Fly   919 SSSAATKASTSSKSSSHSCCQTAEAPSSMTSQSNGCTCRYRRDDGQGEREREHTCQKCTVELANM 983
             |.|:.....:.|::|   |:...|.||.:........|..:..|...|:.|           |.
Mouse   377 -SPASPAPDLTPKTTS---CEKLAATSSTSLLQGQSQIRMCKPPGDRLRQTE-----------NR 426

  Fly   984 KTRSKMDQLRLVMQQHKQKREARKLKSGPYATAASASAADSLSSIAAGG 1032
            .||.|:::|:|::||.:.:|:||:...|||....|..|..|.||.:.||
Mouse   427 ATRCKVERLQLLLQQKRLRRKARRDARGPYHWTPSRKAGRSDSSSSGGG 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stx	NP_572648.1	Ubl_midnolin	69..138	CDD:340502	27/68 (40%)
Midn	NP_067540.1	Ubl_midnolin	32..101	CDD:340502	28/70 (40%)