DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stx and midn

DIOPT Version :9

Sequence 1:	NP_001259426.1	Gene:	stx / 32005	FlyBaseID:	FBgn0052676	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	NP_001015832.1	Gene:	midn / 549445	XenbaseID:	XB-GENE-1005232	Length:	453	Species:	Xenopus tropicalis

Alignment Length:	973	Identity:	195/973 - (20%)
Similarity:	261/973 - (26%)	Gaps:	565/973 - (58%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 VASPMTINLNISTTTGGNFGVSVEPHISVESLKKIIAKKLKVAKDRICLLHREKELQDGTLRDHN 127
            ||....:||||.:|||..:.:||.|..:|:.||:.|:::|||.|:|:.|||||..|..|.|:|..
Frog    14 VARETPMNLNIQSTTGTRYELSVPPDETVDGLKRRISQRLKVPKERLTLLHRETRLSSGKLQDLG 78

  Fly   128 LMDGSKIILIPNVETGLLAQ--RPENTVMQALESLNDAQVNDFLSGKTPLNLSMRLGDHMMLIQL 190
            :.|||::.|:|:||.||::|  |||.:||||||||.:.||||||||::||.|::|:|||||.:||
Frog    79 ISDGSRLTLLPSVEAGLMSQMSRPEQSVMQALESLTETQVNDFLSGRSPLTLALRVGDHMMFVQL 143

  Fly   191 QLSTVNPAGGGAATVAPVAGGASGSSINAAASTTSTVPVMPAGTGCSGANSTSLSSSAVLAAAAA 255
            ||                |...||:|
Frog   144 QL----------------AAQQSGAS--------------------------------------- 153

  Fly   256 GVGGSTGTSGSGTSSSSSSTSSSSSSSSSSSRTRSSGQRSSGRIGHGHVHSHQHPSLHAANWHGF 320

Frog   154 ----------------------------------------------------------------- 153

  Fly   321 SHGHGHGHSHGNGHGHHHHHHHHHHHHHHHHNASAVAAGSGGGMSSLRKMYGDLPSSSGASGSAP 385
                                     |..|.|
Frog   154 -------------------------HLQHRH---------------------------------- 159

  Fly   386 ATGTGQSQSSSTLNGPDLTKLLIKGGIQNIVNSFALKDAGANARPVANGGSGSSPGKPVLEQSPI 450
                            .:|:                   ||.|        |:||....|..|
Frog   160 ----------------VITR-------------------GAEA--------GASPQYRTLHTS-- 179

  Fly   451 KSLSNLVSSPIKMTTIKNIPLPTTAATSSSSSCNCSSAAPSSSSSTSSGACATGGCQQDPIAAKL 515
                                   |:|.|..:||
Frog   180 -----------------------TSALSHLASC-------------------------------- 189

  Fly   516 TSCLCTRLPTPSVAPPVATLVAPAPVARSGSTSSPSKCPESSCSGANAGFAARSTLAGTRVTFSG 580
                     ||...|| .||...|...|.|..|||
Frog   190 ---------TPGSTPP-TTLSPTASTHRDGPHSSP------------------------------ 214

  Fly   581 NSMLHKTGNNRITRTKHRHYHGQGHGHGHGNGHSSSSSSSSSSSSSHFFNHACAGNQPSVNAAAF 645
                       :|.:..|         .||.|.:.|               .||...|
Frog   215 -----------LTTSVFR---------SHGEGVAVS---------------PCAEQVP------- 237

  Fly   646 ATSSSSSSSSPSSSSSSPSKRRKLEQGMGAGAVGATAATATAAATVALPASTSATTAEPDDSLLG 710
                .||..:..:|||:.|:.||
Frog   238 ----CSSRGTEGTSSSASSRSRK------------------------------------------ 256

  Fly   711 VSDTRTLAEASRNLTQTLRKLSKEVFTNKIDLSGAGVVSSGRSSSSGATSSGAASGEEAPRKSGS 775
                                                                            .
Frog   257 ----------------------------------------------------------------P 257

  Fly   776 GAVIESMKNHGKGIYSGTFSGTLNPALQDRFGRPKRDISTVIHILNDLLSATPQYGRGARISFEA 840
            ||:|||..||..|::||||||||:|..||..|||:|||.|::.|||||||||..|
Frog   258 GAIIESFVNHAPGVFSGTFSGTLHPHCQDSAGRPRRDIGTILQILNDLLSATRHY---------- 312

  Fly   841 PTTGSVSGSGSGSGSSGSSSTTSSGSGLHHGSRSKMYSSKHHNCAKCNSRAQQQQQQSATLASGS 905
                        .|...|.:|...                |..||
Frog   313 ------------QGMPPSLTTLRC----------------HTQCA-------------------- 329

  Fly   906 GGSCSFRDCPSYHSSSAATKASTSSKSSSHSCCQTAEAPSSMTSQSNGCTCRYRRDDGQGERERE 970
                          |.|....:||.:||.         |...|.....|..:.|.....|:|.|
Frog   330 --------------SQARNPKATSPQSSE---------PQQTTHPVGHCQAQTRTCKPSGDRLR- 370

  Fly   971 HTCQKCTVELANMKTRSKMDQLRLVMQQHKQKREARKLKSGPY--ATAASASAADSLSSIAAG 1031
                    :..|..||.|:::|:|:|.|.:.:|:||:....||  .....:|...|.||.::|
Frog   371 --------QTENRATRCKVERLQLLMHQKRLRRKARRDSRAPYHWMPTRKSSRTSSNSSTSSG 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stx	NP_001259426.1	UBQ	66..145	CDD:320785	36/78 (46%)
midn	NP_001015832.1	Ubl_midnolin	20..89	CDD:340502	32/68 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	185..219		15/116 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	231..256		9/35 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..374		13/61 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	390..434		11/36 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I10096
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1159802at2759
OrthoFinder	1	1.000	-	-		FOG0009367
OrthoInspector	1	1.000	-	-		oto102940
Panther	1	1.100	-	-	LDO	PTHR23010
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5240
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.140