DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stx and midn

DIOPT Version :9

Sequence 1:	NP_001259426.1	Gene:	stx / 32005	FlyBaseID:	FBgn0052676	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	XP_005170493.1	Gene:	midn / 323713	ZFINID:	ZDB-GENE-030131-2433	Length:	537	Species:	Danio rerio

Alignment Length:	1024	Identity:	204/1024 - (19%)
Similarity:	295/1024 - (28%)	Gaps:	562/1024 - (54%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 TAAGCGSNNSSSTSSSNNTANSNNALQRLATTTSAVVASPMTINLNISTTTGGNFGVSVEPHISV 91
            :|..|.|..::.:..|                    |:....:||.|.:|||..|.:|:....:|
Zfish    34 SARSCSSRGAAPSCES--------------------VSGEPPMNLYIHSTTGTRFELSLPAEETV 78

  Fly    92 ESLKKIIAKKLKVAKDRICLLHREKELQDGTLRDHNLMDGSKIILIPNVETGLLAQ--RPENTVM 154
            |.||:.::::|||.|:|:.|||:|..|..|.|:|..:.||||:.|:|.||.||::|  |||.:||
Zfish    79 EGLKRRLSQRLKVPKERLALLHKETRLSSGKLQDLGITDGSKLTLVPTVEAGLMSQASRPEQSVM 143

  Fly   155 QALESLNDAQVNDFLSGKTPLNLSMRLGDHMMLIQLQLSTVNPAGGGAATVAPVAGGASGSSINA 219
            ||||||.:.||:|||||::||.|::|:|||||.:||||: ..|:||
Zfish   144 QALESLTETQVSDFLSGRSPLTLALRVGDHMMFVQLQLA-AQPSGG------------------- 188

  Fly   220 AASTTSTVPVMPAGTGCSGANSTSLSSSAVLAAAAAGVGGSTGTSGSGTSSSSSSTSSSSSSSSS 284
                                  ..|....:::.     |.|.||:
Zfish   189 ----------------------PQLQHRHLISR-----GSSEGTT-------------------- 206

  Fly   285 SSRTRSSGQRSSGRIGHGHVHSHQHPSLHAANWHGFSHGHGHGHSHGNGHGHHHHHHHHHHHHHH 349
                                              |.||| ..|.:.|.....|:.|.||.|.|.|
Zfish   207 ----------------------------------GLSHG-ASGSASGMARVSHNPHPHHPHQHPH 236

  Fly   350 HHNASAVAAGSGGGMSSLRKMYGDLPSSSGASGSAPATGTGQSQSSSTLNGPDLTKLLIKGGIQN 414
            |.|.:                   |||:..|...:|
Zfish   237 HPNTT-------------------LPSNPAAFPPSP----------------------------- 253

  Fly   415 IVNSFALKDAGANARPVANGGSGSSPGKPVLEQSPIKSLSNLVSSPIKMTTIKNIP-LPTTAATS 478
                                                                 :|| :|...:||
Zfish   254 -----------------------------------------------------SIPSIPPMYSTS 265

  Fly   479 SSSSCN---CSSAAPSS--SSSTSSGACATGGCQQDPIAAKLTSCLCTRLPTPSVAPPVATLVAP 538
            :|..|:   ..|..|.|  .|...|.|||                     |:||         :|
Zfish   266 ASGHCSPPPQPSQLPGSFLHSQQPSSACA---------------------PSPS---------SP 300

  Fly   539 APVARSGSTSSPSKCPESSCSGANAGFAARSTLAGTRVTFSGNSMLHKTGNNRITRTKHRHYHGQ 603
            :|.|         .|||:|||...:|
Zfish   301 SPAA---------SCPEASCSAKTSG--------------------------------------- 317

  Fly   604 GHGHGHGNGHSSSSSSSSSSSSSHFFNHACAGNQPSVNAAAFATSSSSSSSSPSSSSSSPSKRRK 668
                                                                   :.::|.:.||
Zfish   318 -------------------------------------------------------NCNTPLRSRK 327

  Fly   669 LEQGMGAGAVGATAATATAAATVALPASTSATTAEPDDSLLGVSDTRTLAEASRNLTQTLRKLSK 733

Zfish   328 ----------------------------------------------------------------- 327

  Fly   734 EVFTNKIDLSGAGVVSSGRSSSSGATSSGAASGEEAPRKSGSGAVIESMKNHGKGIYSGTFSGTL 798
                                                     .||:|||..||..|::||||||||
Zfish   328 -----------------------------------------PGAIIESFVNHAPGVFSGTFSGTL 351

  Fly   799 NPALQDRFGRPKRDISTVIHILNDLLSATPQYGRGARISFEAPTTGSVSGSGSGSGSSGSSSTTS 863
            :|..||..|||:|||.|::.|||||||||..|
Zfish   352 HPNCQDSTGRPRRDIGTILQILNDLLSATRHY--------------------------------- 383

  Fly   864 SGSGLHHGSRSKMYSSKHHNCAKCNSRAQQQQQQSATLASGSGGSCSFRDCPSYHSSSAATKAST 928
              .|:........|.::   |...||.|                       ||...|...|...|
Zfish   384 --QGMPPSLTQLRYQTQ---CTSPNSPA-----------------------PSPPPSPPHTTGLT 420

  Fly   929 SSKSSSHSCCQTAEAPSSMTSQSN-------GCTCRYRRDDGQGEREREHTCQKCTVELANMKTR 986
            .             .|:::.|::.       .|..:.|.....|:|.|         :..|..||
Zfish   421 G-------------LPTTVPSETQPTLHPLVQCQSQIRMCKPPGDRLR---------QTENRATR 463

  Fly   987 SKMDQLRLVMQQHKQKREARKLKSGPY--ATAASASAADSLSSIAAGGT 1033
            .|:::|:|:|||.:.:|:||:....||  .....|..::|.||:::.|:
Zfish   464 CKVERLQLLMQQKRLRRKARRDSRAPYHWLPNRKAGRSNSNSSMSSEGS 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stx	NP_001259426.1	UBQ	66..145	CDD:320785	34/78 (44%)
midn	XP_005170493.1	midnolin_N	55..132	CDD:176399	34/76 (45%)
midn	XP_005170493.1	UBQ	56..124	CDD:214563	29/67 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582220
Domainoid	1	1.000	58	1.000	Domainoid score	I10782
eggNOG	1	0.900	-	-		E1_28KXC
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	257	1.000	Inparanoid score	I3139
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1159802at2759
OrthoFinder	1	1.000	-	-		FOG0009367
OrthoInspector	1	1.000	-	-		oto40478
orthoMCL	1	0.900	-	-		OOG6_110744
Panther	1	1.100	-	-	LDO	PTHR23010
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5240
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.880