Protein Alignment Rph and SYTL5

DIOPT Version :10

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: NP_001156806.1
• Gene: SYTL5 / 94122
• HGNCID: 15589
• Length: 752
• Species: Homo sapiens
• Alignment Length: 747
• Identity: 167/747 - (22%)
• Similarity: 278/747 - (37%)
• Gaps: 188/747 - (25%)

  Fly    34 SKTSE-----PLRPEEQEAIISVIRRNEEIEVAERQRVGRLVERVEKIKQHA---VERGPNCCRL 90
            ||.||     .|...|:|.|:.|::|:|.::..|.:|:.:|...:.:.|:.:   .:.....|..
Human     2 SKNSEFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQQEASRVCVH 66

  Fly    91 CGDTFGILRPQRILCEDCRQSVCTKCSVDINIRYHTSERSREIWLCRICSETREMWKKSGAWFFK 155
            |....|::..:...|:.|...||.:|.|         ......|.|.:|.:..::...:|.|||:
Human    67 CHRNLGLIFDRGDPCQACSLRVCRECRV---------AGPNGSWKCTVCDKIAQLRIITGEWFFE 122

  Fly   156 GLPKYDMPRSASATPI-------PNPGPGSMAGDTRAVQSCHATPTRPARVKK------------ 201
            ...|.....:...|.:       .:||...:....:..|....:.|.|...||
Human   123 EKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAEKSDTSPVAGKKASHDGPKRKGFL 187

  Fly   202 ------------LTIRVN---------------------DSSSSSSGHSEPEDEVDTG-----VG 228
                        :|.:.:                     .|...|:|.|:..|: :.|     ..
Human   188 LSKFRSATRGEIITPKTDTGRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDLNDQ-EPGPRTPKSS 251

  Fly   229 IGVGVVGGGMAKGIASTRLQREDSFRLRAYGSIRSF----IDGGERKLSNSFFFNRQQSQRPSEC 289
            ...||..|..:....|||  ...|...|.||...|.    |:|..::|:.|  ..|..|..||..
Human   252 RSNGVTPGTQSSPAPSTR--TVTSVISREYGFENSMDLAAIEGTSQELTKS--HRRNTSGTPSIA 312

  Fly   290 PEYDSVSMSKLRRE----SSF---------LRRGS--------------------VSSSWS---- 317
            ....|:|..:.|.|    .||         :|..|                    |||..|
Human   313 VSGTSLSSDQSRSELDLSESFTEDSEDTVSIRSKSVPGALDKDSLEETEESIDALVSSQLSTNTH 377

  Fly   318 -----ISDSSGSGSNN--------SGNSQTQS--QYQQHQQQLQQHCRDPLLGWLEIAISYREAF 367
                 :|.||.:||:.        ..:|.|.|  .......:...:....:.|.:.:.|||....
Human   378 RLASGLSTSSQAGSDRKWTYLNVPDADSDTTSLNSMMSVYSETGDYGNVKVSGEILLHISYCYKT 442

  Fly   368 HSLDCTMVRARDLPAMD-AAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKT-RNPEFNETLQFV 430
            ..|...:...|:|...| .....|.|.| :.:.|:.    :|..:.||..:| .||||||||::.
Human   443 GGLYIFVKNCRNLAIGDEKKQRTDAYVK-SYLLPDK----SRNNKRKTKIRTGTNPEFNETLKYT 502

  Fly   431 GVEPEELGNSLIYVALFDDDKYG-HDFLGAAKVCLST---VHSTSQYRISVP-------LGVEDQ 484
             :...:|....:.::::..|::| :.|||..::...:   .:.|.::.:..|       :|:  |
Human   503 -ISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPTDEWFVLQPKVEFAPDIGL--Q 564

  Fly   485 YSNAAEMAQNW--PNGKMLL---------SLCYNTKRRALVVN-------VKQCINLMAMDNNGS 531
            |.....:...:  |...::|         :.....|:.:.|::       :|:..||.|:.:.|:
Human   565 YKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKESPVISGGILEVFIKEAKNLTAVKSGGT 629

  Fly   532 SDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEA-SPHDLNKEMLILTVWDKDLGKSND 595
            ||.|||..|.||..|..||||.|..:::||.:|..|.|.. .|.|:....|.||:|||:...||.
Human   630 SDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNI 694

  Fly   596 FLGSLQLGA-------------QSKGERLQQW 614
            |||.::|.:             .|:||..:.|
Human   695 FLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLW 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710	18/94 (19%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	31/128 (24%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	45/146 (31%)
SYTL5	NP_001156806.1	PHD_SF	11..123	CDD:473978	27/120 (23%)
		FYVE_Slp5	62..108	CDD:277305	12/54 (22%)
		AF-4	<218..>376	CDD:461550	37/162 (23%)
		C2A_SLP-4_5	429..552	CDD:175995	31/128 (24%)
		C2B_SLP_1-2-3-4	566..744	CDD:175987	46/161 (29%)