Protein Alignment Rph and SYTL4

DIOPT Version :10

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: NP_001357091.1
• Gene: SYTL4 / 94121
• HGNCID: 15588
• Length: 676
• Species: Homo sapiens
• Alignment Length: 665
• Identity: 157/665 - (23%)
• Similarity: 264/665 - (39%)
• Gaps: 156/665 - (23%)

  Fly    40 LRPEEQEAIISVIRRNEEIEVAERQRVGRLVERVEKIKQHAVERG-----PNCCRLCGDTFGILR 99
            |..||::.|:||::|:||:..|:.:|:.||...:.:||:...:||     ...|..|.::.|.|.
Human    10 LSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKRGSQHYSDRTCARCQESLGRLS 74

  Fly   100 PQRILCEDCRQSVCTKCSVDINIRYHTSERSREIWLCRICSETREMWKKSGAWFF---------- 154
            |:...|..|...||..|.:         :.|...|.|::|::..|:.|.:|.||:
Human    75 PKTNTCRGCNHLVCRDCRI---------QESNGTWRCKVCAKEIELKKATGDWFYDQKVNRFAYR 130

  Fly   155 ----------KGLPKYDMPRSASATPIPNPGPGSMAGDTRAVQSCHATPTRPARVKKLTIRVN-- 207
                      :..|......:...:.:.....|.:....:.:|.....|:....|.||....:
Human   131 TGSEIIRMSLRHKPAVSKRETVGQSLLHQTQMGDIWPGRKIIQERQKEPSVLFEVPKLKSGKSAL 195

  Fly   208 -------DSSSSSSGHSEPEDEVDTGVGIGVGVVGGGMAKGIASTRLQREDSFRLRAYGSIRSFI 265
                   ||.::.|..:...|.:|..     |:...........:::::|    .:..|....|:
Human   196 EAESESLDSFTADSDSTSRRDSLDKS-----GLFPEWKKMSAPKSQVEKE----TQPGGQNVVFV 251

  Fly   266 DGGERKLSNSFFFNRQQSQRPSEC--------PE---YDSVSMS--------------------- 298
            |.||.    .|..|.::..||||.        ||   ::|.|:.
Human   252 DEGEM----IFKKNTRKILRPSEYTKSVIDLRPEDVVHESGSLGDRSKSVPGLNVDMEEEEEEED 312

  Fly   299 -----KLRRES---SFLRRGS----VSSSWSISDSSGSGSN--NSGNSQTQSQYQQHQQQLQQHC 349
                 ||.|:.   |.::.||    :.|..||...:|...|  .:|......:|:|..|.|..|.
Human   313 IDHLVKLHRQKLARSSMQSGSSMSTIGSMMSIYSEAGDFGNIFVTGRIAFSLKYEQQTQSLVVHV 377

  Fly   350 RDPLLGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKT 414
            :                    :|..:...|    :|...::||.|..:: |:...:..|  :|..
Human   378 K--------------------ECHQLAYAD----EAKKRSNPYVKTYLL-PDKSRQGKR--KTSI 415

  Fly   415 VHKTRNPEFNETLQFVGVEPEE-LGNSLIYVALFDDDKYGHD-FLGAAKVCLSTVHSTSQYRISV 477
            ...|.||.::|||::  ..||. |....:..:::...::|.: |||.|::.:.:.....:....:
Human   416 KRDTINPLYDETLRY--EIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCL 478

  Fly   478 PLGVEDQYSNAAEMAQNWPN--GKMLLSLCY---------NTKRRA-------LVVNVKQCINLM 524
            ||    ....:||.....|:  |::::||.|         ..::::       |.|.:|:..||.
Human   479 PL----HGKISAESPTGLPSHKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKNLT 539

  Fly   525 AMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEF-YFEASPHDLNKEMLILTVWDK 588
            |....|:||.|||..|.|..:|..|.||.|..:||||.||..| |......||....|.|||||:
Human   540 AAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVWDR 604

  Fly   589 DLGKSNDFLGSLQLG 603
            :...||||||.::||
Human   605 EPLASNDFLGGVRLG 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710	21/112 (19%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	23/124 (19%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	46/122 (38%)
SYTL4	NP_001357091.1	PHD_SF	8..121	CDD:473978	36/119 (30%)
		FYVE_Slp4	58..107	CDD:277303	14/57 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	199..243		7/52 (13%)
		C2A_SLP-4_5	357..481	CDD:175995	31/156 (20%)
		C2B_SLP_1-2-3-4	496..>622	CDD:175987	47/124 (38%)