Protein Alignment Rph and SYT7

DIOPT Version :10

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: XP_011543637.1
• Gene: SYT7 / 9066
• HGNCID: 11514
• Length: 692
• Species: Homo sapiens
• Alignment Length: 579
• Identity: 143/579 - (24%)
• Similarity: 218/579 - (37%)
• Gaps: 148/579 - (25%)

  Fly   158 PKYDMPRSASATPIPNPGPGSMA--GDTRAVQS----------------------CHATPTRPAR 198
            |..|..||..|.| ..||.|..|  |..|.|||                      ..:.|:....
Human   155 PGEDALRSGGAAP-SEPGSGGKAGRGRWRTVQSHLAAGKLNLSNFEDSTLSTATTLESIPSSTGE 218

  Fly   199 VK----KLTIRVNDSSSSSSGH------SEPEDEVDTG---------VGIGVGVVGGGMAK-GIA 243
            .|    :..:|........|.|      |:|......|         .|......|.|.|: |.:
Human   219 PKCQRPRTLMRQQSLQQPLSQHQRGRQPSQPTTSQSLGQLQAHMASAPGPNPRAYGRGQARQGTS 283

  Fly   244 STRLQREDSFRLRA--------YGSIR-------SFIDGGERKLS-------NSFFFN------- 279
            :....|....|.|:        .|.||       ||::|....||       ...|.|
Human   284 AGSKYRAAGGRSRSNPGSWDHVVGQIRNRGLDMKSFLEGRMVVLSLVLGLSEQDDFANIPDLQNP 348

  Fly   280 -RQQSQR-------------------PSECPEYDSVSMSKLRRESSFLRRGSVSSSWSISDSSGS 324
             .||:|.                   |.:.|..:|...::.|...|.|.....|....:|..|
Human   349 GTQQNQNAQGDKRLPAGGKAVNTAPVPGQTPHDESDRRTEPRSSVSDLVNSLTSEMLMLSPGS-- 411

  Fly   325 GSNNSGNSQTQSQYQQHQQQLQQHCRDPLLGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLA 389
                            .:.:..:.|....||.::.::.|.....:|...:::|::|||.|.:|.:
Human   412 ----------------EEDEAHEGCSRENLGRIQFSVGYNFQESTLTVKIMKAQELPAKDFSGTS 460

  Fly   390 DPYCKLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYG- 453
            ||:.|:.::..:.|.     ..||...|..||.:|||..|.|...|::...::|:.:.|.|::.
Human   461 DPFVKIYLLPDKKHK-----LETKVKRKNLNPHWNETFLFEGFPYEKVVQRILYLQVLDYDRFSR 520

  Fly   454 HDFLGAAKVCLSTVHSTSQYRISVPLGVEDQYSNAAEMAQNWPN-----------GKMLLSLCYN 507
            :|.:|               .:|:||...|    ..:|...|.:           |::|||||||
Human   521 NDPIG---------------EVSIPLNKVD----LTQMQTFWKDLKPCSDGSGSRGELLLSLCYN 566

  Fly   508 TKRRALVVNVKQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEAS 572
            ....:::||:.:..||.|||..|:|||:||:.|.....:.:|.||....|.||||:||.|.|:..
Human   567 PSANSIIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTMKRNLNPIFNESFAFDIP 631

  Fly   573 PHDLNKEMLILTVWDKDLGKSNDFLGSLQLGAQSKGERLQQWLDCIRLPDHFHEKWHCL 631
            ...|.:..:|:||.|||....||.:|.:.|..:|....::.|.|.|..|.....:||.|
Human   632 TEKLRETTIIITVMDKDKLSRNDVIGKIYLSWKSGPGEVKHWKDMIARPRQPVAQWHQL 690

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710	6/13 (46%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	30/123 (24%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	51/131 (39%)
SYT7	XP_011543637.1	PHA03307	<149..>316	CDD:223039	34/161 (21%)
		C2A_Synaptotagmin-7	424..548	CDD:176032	36/147 (24%)
		C2B_Synaptotagmin-7	556..691	CDD:176050	53/135 (39%)