Protein Alignment Rph and SYT8

DIOPT Version :10

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: NP_001277261.2
• Gene: SYT8 / 90019
• HGNCID: 19264
• Length: 402
• Species: Homo sapiens
• Alignment Length: 270
• Identity: 76/270 - (28%)
• Similarity: 123/270 - (45%)
• Gaps: 31/270 - (11%)

  Fly   355 GWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKTVHK-T 418
            |.|::::.:......:...:.:|.||   ...|..|||.::::.|...|...|:      ||: |
Human   120 GCLQLSLEFDFGSQEIRVGLRQAADL---RPGGTVDPYARVSVSTQAGHRHETK------VHRGT 175

  Fly   419 RNPEFNETLQFVGVEPEELGNSLIYVALFDDDKY-GHDFLGAAKVCLSTV---HSTSQ-YRISVP 478
            ..|.|:||..| .:...||..:.:.|.||:..:: ||:.||..::.|.||   |.... |.:..|
Human   176 LCPVFDETCCF-HIPQAELPGATLQVQLFNFKRFSGHEPLGELRLPLGTVDLQHVLEHWYLLGPP 239

  Fly   479 LGVEDQYSNAAEMAQNWPNGKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQLKPD 543
            ...:.:..           |::..||.|......|.|.|.:...|    ..|.::|:||:||..:
Human   240 AATQPEQV-----------GELCFSLRYVPSSGRLTVVVLEARGL----RPGLAEPYVKVQLMLN 289

  Fly   544 AHKNKKHKTSVKWRTLNPIYNEEFYFEASPHDLNKEMLILTVWDKDLGKSNDFLGSLQLGAQSKG 608
            ..|.||.||:.|..|..|.:||.|.|......:....|:|.|||:.|....:.:|.:.|||::.|
Human   290 QRKWKKRKTATKKGTAAPYFNEAFTFLVPFSQVQNVDLVLAVWDRSLPLRTEPVGKVHLGARASG 354

  Fly   609 ERLQQWLDCI 618
            :.||.|.|.:
Human   355 QPLQHWADML 364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710
		C2A_Rabphilin_Doc2	354..477	CDD:176000	34/127 (27%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	40/120 (33%)
SYT8	NP_001277261.2	C2	120..233	CDD:472691	33/122 (27%)
		C2	248..377	CDD:472691	41/121 (34%)