Protein Alignment Rph and SYTL1

DIOPT Version :10

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: XP_005246079.1
• Gene: SYTL1 / 84958
• HGNCID: 15584
• Length: 594
• Species: Homo sapiens
• Alignment Length: 699
• Identity: 151/699 - (21%)
• Similarity: 247/699 - (35%)
• Gaps: 195/699 - (27%)

  Fly     1 MDFQNRNNTANK---------FVCPSDRQLALRAKLKAGWSSSK-----TSEP------------ 39
            |...:|..||.|         .|||:..|..|..  :.|..|.:     .|.|
Human     1 MGLSHRVKTAEKTKLLPNSGSSVCPAGAQPQLMP--QRGHPSQEGLWALPSLPMAHGPKPETEGL 63

  Fly    40 -----LRPEEQEAIISVIRRNEEIEVAERQRVGRLVERVEKIKQHAVERGPNCCRLCGDTFGILR 99
                 |..||||||..|::|:..:...|..||.:|...|....|..:        |.||.|...|
Human    64 LDLSFLTEEEQEAIAGVLQRDARLRQLEEGRVSKLRASVADPGQLKI--------LTGDWFQEAR 120

  Fly   100 PQRILCEDCRQSVCTKCSVDINIRYHTSERSREIWLCRICSETREMWKKSGAWFFKGLPKYDMPR 164
            .|                     |:|.:....:  |.|.....::..:...|      |.:|  |
Human   121 SQ---------------------RHHNAHFGSD--LVRASMRRKKSTRGDQA------PGHD--R 154

  Fly   165 SASAT-------PIP----NPGPGSMAGDTRAVQSCHATPTRPARVKKLTIRVNDSSSSSSGHSE 218
            .|.|.       |.|    :..|.....:|..       |..|:  ..:.::.:|...:|....:
Human   155 EAEAAVKEKEEGPEPRLTIDEAPQERLRETEG-------PDFPS--PSVPLKASDPEEASQAQED 210

  Fly   219 P--------EDEVDTGVGIGVGVVGGGMAKGIASTRLQREDSFRLRAYGSIRSFIDGGERKLSNS 275
            |        .:|.|..:....|        |....|.|:..:   :|...|   ::.||
Human   211 PGQGDQQVCAEEADPELEPASG--------GEQEPRPQQAQT---KAASQI---LENGE------ 255

  Fly   276 FFFNRQQSQRPSECPEYDSVSMSKLRRESSFLRRGSVSSSWSISDSSGSGSNNSGNSQTQSQYQQ 340
                    :.|...|..|.:           |...|..||.:.|..|||..:.||:::...
Human   256 --------EAPGPDPSLDRM-----------LSSSSSVSSLNSSTLSGSQMSLSGDAEAVQ---- 297

  Fly   341 HQQQLQQHCRDPLLGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTK 405
                        :.|.:..|:.|......|...:::.:.|.|. ....:|||.| :.:.|:..:|
Human   298 ------------VRGSVHFALHYEPGAAELRVHVIQCQGLAAA-RRRRSDPYVK-SYLLPDKQSK 348

  Fly   406 YTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYGHD-FLGAAKVCLSTVHS 469
                ::|....:..||.|||||:: .|...||...::.::::..:..|.: |||..:|.|.|...
Human   349 ----RKTAVKKRNLNPVFNETLRY-SVPQAELQGRVLSLSVWHRESLGRNIFLGEVEVPLDTWDW 408

  Fly   470 TSQ-----YRISVPLGVEDQYSNAAEMAQNWPNGKMLLSLCY---NTKRRALVVN------VKQC 520
            .|:     .:..||...:|..|          .|.:.|||.|   .::...|..:      ||:.
Human   409 GSEPTWLPLQPRVPPSPDDLPS----------RGLLALSLKYVPAGSEGAGLPPSGELHFWVKEA 463

  Fly   521 INLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEA-SPHDLNKEMLILT 584
            .:|:.: ..||.|.:|:..:.||..:..:.:|.|..|:|:|::|....::. .|.||.:....|:
Human   464 RDLLPL-RAGSLDTYVQCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACAELS 527

  Fly   585 VWDKDLGKSNDFLGS--LQLGAQSKGERLQQWLDCIRLPDHFHEKWHCL 631
            :||.. ..:|..||.  |.||..|.......|:|  ..|:. .:.|..|
Human   528 LWDHG-ALANRQLGGTRLSLGTGSSYGLQVPWMD--STPEE-KQLWQAL 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710	17/94 (18%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	31/128 (24%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	37/143 (26%)
SYTL1	XP_005246079.1	PHD_SF	67..>131	CDD:473978	23/92 (25%)
		PHA03169	94..>261	CDD:223003	41/242 (17%)
		C2A_SLP-1_2	299..418	CDD:176039	31/125 (25%)
		C2B_SLP_1-2-3-4	431..587	CDD:175987	39/147 (27%)