DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rph and DOC2A

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	XP_024306240.1	Gene:	DOC2A / 8448	HGNCID:	2985	Length:	467	Species:	Homo sapiens

Alignment Length:	497	Identity:	149/497 - (29%)
Similarity:	224/497 - (45%)	Gaps:	95/497 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 RPARVKKLTIRVNDSSSSS--SGHSEPEDEVDTGVGIGVGVVGGGMAKGIASTRL---------- 247
            |..|..::||.:.:..:.:  .|...|..::......|.|..|||...|.|...|
Human     2 RGRRGDRMTINIQEHMAINVCPGPIRPIRQISDYFPRGPGPEGGGGGGGEAPAHLVPLALAPPAA 66

  Fly   248 -----QREDSFRLRAYGSIRSFIDGGERKLSNSFFFNRQQSQRPSECPEYDSVSMSKLRRESSFL 307
                 ..||...:.:|.|..:...|   .|.....::|      :.|..:.|:..:|:
Human    67 LLGATTPEDGAEVDSYDSDDATALG---TLEFDLLYDR------ASCTLHCSILRAKV------- 115

  Fly   308 RRGSVSSSWSISDSSGSGSNNS-GNSQTQSQYQQHQQQLQQHC-------------RDPLL--GW 356
                           |:..:.| |....|.....|.....|.|             :.|.|  ||
Human   116 ---------------GTPCHPSPGPVCVQPPEGAHSSFPSQACSFVLPLPPPSGLLQGPALQEGW 165

  Fly   357 LEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKTRNP 421
            .|:.    .|...|.|..::.  |..||..||||||.||::: |.| .|..: .:|||...|.||
Human   166 REVP----GASSPLPCPPLQG--LKPMDFNGLADPYVKLHLL-PGA-CKANK-LKTKTQRNTLNP 221

  Fly   422 EFNETLQFVGVEPEELGNSLIYVALFDDDKYGH-DFLGAAKVCLSTVHSTSQYRIS------VPL 479
            .:||.|.:.|:..:::.:.::.:|:.|:||..| :|:|..:|.|..:..:.:...:      |||
Human   222 VWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPL 286

  Fly   480 GVEDQYSNA-------------AEMAQNW--PNGKMLLSLCYNTKRRALVVNVKQCINLMAMDNN 529
            ......|.|             ||..|..  ..|::||||.|:::||.|:|.:.:|.:|.|||.|
Human   287 ASPSSMSAALRGISCYLKELEQAEQGQGLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVN 351

  Fly   530 GSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASPHDLNKEMLILTVWDKDLGKSN 594
            |.|||:||..|:||..|..||||.||.:||||.:||||::|.....|..:.|.:||||.|:||||
Human   352 GYSDPYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSN 416

  Fly   595 DFLGSLQLGAQSKGERLQQWLDCIRLPDHFHEKWHCLAPDNP 636
            ||:|.:.||..::||..:.|.||::.||...|:||.|..:.|
Human   417 DFIGGVSLGPGARGEARKHWSDCLQQPDAALERWHTLTSELP 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	40/131 (31%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	66/131 (50%)
DOC2A	XP_024306240.1	C2A_Rabphilin_Doc2	90..280	CDD:176000	54/229 (24%)
DOC2A	XP_024306240.1	C2B_Rabphilin_Doc2	321..453	CDD:176030	66/131 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	127	1.000	Domainoid score	I5357
eggNOG	1	0.900	-	-		E1_KOG1013
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185575at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	1	1.000	-	-		otm40625
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45729
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2745
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.910