DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rph and DOC2B

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_003576.2	Gene:	DOC2B / 8447	HGNCID:	2986	Length:	412	Species:	Homo sapiens

Alignment Length:	489	Identity:	152/489 - (31%)
Similarity:	225/489 - (46%)	Gaps:	127/489 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 FFKGLPKYDMPRSASATPIPNPGPGSMAGDTRAVQSCHATPTRPARVKKLTIRVNDSSSSSSGHS 217
            |.:|||             |:.||       ||.    |.|..|||.   .:......|.|.|..
Human    40 FPRGLP-------------PDAGP-------RAA----APPDAPARP---AVAGAGRRSPSDGAR 77

  Fly   218 EPEDEVDTGVGIGVGVVGGGMAKGIASTRLQREDSFRLRAYGSIRSFIDGGERKLSNSFFFNRQQ 282
            |.:::||...|                            ||||......|             ..
Human    78 EDDEDVDQLFG----------------------------AYGSSPGPSPG-------------PS 101

  Fly   283 SQRPSECPEYDSVSMSKLRRESSFLRRGSVSSSWSISDSSGSGSNNSGNSQTQSQYQQHQQQLQQ 347
            ..||...|..|.                        .|:.|..|::
Human   102 PARPPAKPPEDE------------------------PDADGYESDD------------------- 123

  Fly   348 HCRDPLLGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRT 412
             |  ..||.|:.::.|.:..::|.||:.:|:.|..||..||||||.||::: |.| :|..: .||
Human   124 -C--TALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLL-PGA-SKANK-LRT 182

  Fly   413 KTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYGH-DFLGAAKVCLSTV--HSTSQYR 474
            ||:..|.||.:||||.:.|:..|::....:.:::.|:||:.| :|:|..:|.|..:  :.|..:.
Human   183 KTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFS 247

  Fly   475 ISV--PLGVEDQYSNAAEMAQNWPNGKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVK 537
            |.:  .|.|:.....:.|     ..|::|:||.|:::::.|:|.:.:|.:|.|||.||.|||:||
Human   248 ICLEKQLPVDKTEDKSLE-----ERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVK 307

  Fly   538 IQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASPHDLNKEMLILTVWDKDLGKSNDFLGSLQL 602
            ..|:||..|..||||:||.:||||.:||||.:|....||.|:.|.:||||.|:||||||:|.:.|
Human   308 TYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFIGGVVL 372

  Fly   603 GAQSKGERLQQWLDCIRLPDHFHEKWHCLAPDNP 636
            |..:|||||:.|.||::..|...|:||.|..:.|
Human   373 GIHAKGERLKHWFDCLKNKDKRIERWHTLTSELP 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600	4/18 (22%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	45/125 (36%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	67/131 (51%)
DOC2B	NP_003576.2	Mediates interaction with DYNLT1. /evidence=ECO:0000269\|PubMed:9804756	1..90		21/104 (20%)
		Negatively regulates targeting to plasma membrane. /evidence=ECO:0000250	1..36
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..123		33/174 (19%)
		C2A_Rabphilin_Doc2	127..250	CDD:176000	45/125 (36%)
		Mediates interaction with STXBP3. /evidence=ECO:0000250	257..375		57/122 (47%)
		C2B_Rabphilin_Doc2	269..401	CDD:176030	67/131 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	127	1.000	Domainoid score	I5357
eggNOG	1	0.900	-	-		E1_KOG1013
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	352	1.000	Inparanoid score	I2269
Isobase	1	0.950	-	0	Normalized mean entropy	S4254
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185575at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	1	1.000	-	-		otm40625
orthoMCL	1	0.900	-	-		OOG6_106212
Panther	1	1.100	-	-	O	PTHR45729
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2745
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.850