Protein Alignment Rph and SYT15

DIOPT Version :9

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: XP_024303996.1
• Gene: SYT15 / 83849
• HGNCID: 17167
• Length: 474
• Species: Homo sapiens
• Alignment Length: 550
• Identity: 119/550 - (21%)
• Similarity: 185/550 - (33%)
• Gaps: 141/550 - (25%)

  Fly   130 SREIWLCRICSETREMWKK--SGAWFFKGLPKYDMPRSA--SATPIPNPGPGSMAGDTRA----- 185
            ||...|..:...||..|..  ||:           .|||  .:|..|.||||:..|.|.|
Human    12 SRREPLAPLAPGTRPGWSPAVSGS-----------SRSALRPSTAGPGPGPGTGWGGTAASGRWV 65

  Fly   186 -VQSCHATPTRPARVKKLTIRVNDSSSSSSGHSEPEDEVDTGVGIGVGVVGGGMAKGIASTRLQR 249
             ..:.|....|.|            :.....|..|....|.                 |..|.:|
Human    66 PAPAVHCAAPRAA------------AGHQQHHGPPLCSPDG-----------------APRRFKR 101

  Fly   250 EDSFRLRAYGSIRSFIDGGERKLSNSFFFNRQQSQRPSECP-----------------------E 291
            ..       ||.......||..|      ..|....|...|                       .
Human   102 RP-------GSPAPAAQTGETSL------REQPHGGPPAVPFVVPPTLQGRDWVPLHSGEWADAP 153

  Fly   292 YDSVSMSKLRRESSFLRRGSVSSSWSISDSSGSGSNNSGNSQTQSQYQQHQQQLQQHCRDPLLGW 356
            :|....|:|...         :||..:.|:...|:.|      ...|:..:.:.:....|..||.
Human   154 WDPCPASELLPH---------TSSGGLGDACMVGAIN------PELYKFPEDKSETDFPDGCLGR 203

  Fly   357 LEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKTRNP 421
            |..::.|.:....|...:::|:.|.|  .:....|..||.::..|     .|:.::||..||.||
Human   204 LWFSVEYEQEAERLLVGLIKAQHLQA--PSETCSPLVKLYLLPDE-----RRFLQSKTKRKTSNP 261

  Fly   422 EFNETLQFVGVEPEELGNSLIYVALFDDDKY-GHDFLGAAKVCLSTVHSTSQYRISVPLGVEDQY 485
            :|:|...| .|..:.:...::..:::..|:. .|..||               ::..||..|...
Human   262 QFDEHFIF-QVSSKTITQRVLKFSVYHVDRQRKHQLLG---------------QVLFPLKNETLV 310

  Fly   486 SNAAEMAQNWPN------------GKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKI 538
            .:...:.  |.:            |.:...|.||.....|.|.|.:...|...::.|....|||:
Human   311 GDCRRVI--WRDLEAESLEPPSEFGDLQFCLSYNDYLSRLTVVVLRAKGLRLQEDRGIVSVFVKV 373

  Fly   539 QLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASPHDLNKEMLILTVWDKDLGKSNDFLGSLQLG 603
            .|.......|..|||....::||:|||.|.|:|...:|:...|.|||.....|..:..||.:.:|
Human   374 SLMNHNKFVKCKKTSAVLGSINPVYNETFSFKADATELDTASLSLTVVQNMEGDKSQQLGRVVVG 438

  Fly   604 --AQSKGERLQQWLDCIRLPDHFHEKWHCL 631
              ..::|..|:.|.:.:..|....::||.|
Human   439 PYMYTRGRELEHWDEMLSKPKELVKRWHAL 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600	12/45 (27%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	27/123 (22%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	39/133 (29%)
SYT15	XP_024303996.1	C2A_Synaptotagmin-15-17	202..322	CDD:176036	30/144 (21%)
		C2B_Synaptotagmin-15	332..469	CDD:176054	40/136 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910