Protein Alignment Rph and Sytl3

DIOPT Version :10

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: NP_113572.1
• Gene: Sytl3 / 83672
• MGIID: 1933367
• Length: 607
• Species: Mus musculus
• Alignment Length: 688
• Identity: 146/688 - (21%)
• Similarity: 250/688 - (36%)
• Gaps: 201/688 - (29%)

  Fly    38 EPLRPEEQEAIISVIRRNEEIEVAERQRVGRLVERVEKI-----KQHAVERGPNCCRLCGDTFGI 97
            |..:..|::.|:.|:.|::.::..|.:||.:|...::.:     |..:.|....||..|....|:
Mouse     8 ESFKELERDIILRVLYRDQTVQSTEEERVRKLKSHLQHLRWKGAKSSSQEYKEKCCARCQRALGL 72

  Fly    98 LRPQRILCEDCRQSVCTKCSVDINIRYHTSERSREIWLCRICSETREMWKKSGAWFF-------- 154
            |..:..:|:.|...||::|.|.:        |....|.|.:|.|.|.:..|:|.|||
Mouse    73 LLNRGAVCQGCSHRVCSECRVFL--------RRTRAWKCTVCFEDRNVKIKTGEWFFEERARKFP 129

  Fly   155 ----------KGLPKYDMPRSASATPIPNPGP---------------GSMAGDTRAVQSCHATPT 194
                      |.|..|......|..| |.|.|               |...|..::|::...:.|
Mouse   130 TAGRRETAGAKLLQSYQRLSKISVVP-PTPPPFSESQCSSSSRLQELGHFRGFNKSVENLFLSVT 193

  Fly   195 RPARVKKLTIRVNDSSSSSS----------GHSEPEDEVDTGVGIGVGVVGGGMAKGIASTRLQR 249
              .:::||:...||.:|...          ||:|...:.||.|             .:.|.:...
Mouse   194 --TQMRKLSKSQNDMTSEKHLLAMDPRQCVGHTERRSQSDTAV-------------NVTSRKAST 243

  Fly   250 EDSFRLRAYGSIRSFIDGGERKLSNSFFFNRQQSQRPSE----------CPEYDSVSMSKLRRES 304
            .|..:.                      |:::..:.|.:          .|.:.:|.       |
Mouse   244 PDILKA----------------------FHQEDPKHPPDPVLKQDTPPSSPTHSAVF-------S 279

  Fly   305 SFLRRGSVSSSWSISDSSGSGSNNSGNSQTQSQYQQHQQQLQQHCRDPLLGWLEIAISYREAFHS 369
            ..||.||:.|..|.....|:..|.:                       :.|.:|.||.|.....|
Mouse   280 GGLRHGSLISINSTCTEMGNFDNAN-----------------------VTGEIEFAIHYCVKSCS 321

  Fly   370 LDCTMVRARDLP-AMDAAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVE 433
            |:..:...::|. ..:.....:||.|..:: |:..::..|  :|:....|.:|.|.|||:: .|:
Mouse   322 LEICIKTCKNLAYGEEKKRKCNPYVKTYLL-PDRSSQGKR--KTRVQKNTLDPTFEETLKY-QVD 382

  Fly   434 PEELGNSLIYVALFDDDKYGHDFLG--AAKVCLSTVHSTSQYRISVPLGVEDQYSNAAEMAQNWP 496
            |.:|....:.|:::        .||  |.:|.|.        .:.:||.:.|...:.|:.|:.:|
Mouse   383 PGQLMTRRLQVSVW--------HLGTLARRVFLG--------EVILPLAMWDFKDSTAQNARWYP 431

  Fly   497 ---------------NG------KMLLSLCYNTKRRA----LVVNVKQCINLMAMDN-----NGS 531
                           ||      |::|.......:.|    |.:|.:.|:.::...|     :|:
Mouse   432 LRAKAEKYEENIPQNNGELAVRAKLVLPAGPRKPQEAQEGQLALNGQLCLVVLGAKNLPVRSDGT 496

  Fly   532 SDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFE-ASPHDLNKEMLILTVWDKDLGKSND 595
            .:.|||..|.....:..:.|:.|..:...|.:...|.|. .|...|.:..|.|||||:.:...||
Mouse   497 LNSFVKGCLTLPNQQKLRVKSPVLKKQACPQWKHSFVFNGVSSSQLRQSTLELTVWDQAIFGMND 561

  Fly   596 -FLGSLQLGAQSKGERLQQWLDCIRLPDHFHE---KWH 629
             .||..:||  |||       .....||...:   :||
Mouse   562 RLLGEARLG--SKG-------GAAGCPDSGSQSKLQWH 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710	27/105 (26%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	29/125 (23%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	38/145 (26%)
Sytl3	NP_113572.1	PHD_SF	14..123	CDD:473978	32/116 (28%)
		FYVE_like_SF	60..108	CDD:333710	15/55 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	221..279		12/99 (12%)
		C2	306..433	CDD:472691	35/146 (24%)
		C2B_SLP_1-2-3-4	447..607	CDD:175987	40/153 (26%)