DRSC/TRiP Functional Genomics Resources

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Protein Alignment Rph and Doc2b

DIOPT Version :10

Sequence 1:NP_572651.1 Gene:Rph / 32002 FlyBaseID:FBgn0030230 Length:638 Species:Drosophila melanogaster
Sequence 2:NP_112404.1 Gene:Doc2b / 81820 RGDID:620519 Length:412 Species:Rattus norvegicus


Alignment Length:486 Identity:149/486 - (30%)
Similarity:222/486 - (45%) Gaps:121/486 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   153 FFKGLPKYDMPRSASATPIPNPGPGSMAGDTRAVQSCHATPTRPARVKKLTIRVNDSSSSSSGHS 217
            |.:|||....||:::....|...|.:.||           |..|                |.|..
  Rat    40 FPRGLPPTAAPRASAPPDAPARSPAATAG-----------PRSP----------------SDGAR 77

  Fly   218 EPEDEVDTGVGIGVGVVGGGMAKGIASTRLQREDSFRLRAYGSIRSFIDGGERKLSNSFFFNRQQ 282
            :.:::||...|                            |||:......|             ..
  Rat    78 DDDEDVDQLFG----------------------------AYGASPGPSPG-------------PS 101

  Fly   283 SQRPSECPEYDSVSMSKLRRESSFLRRGSVSSSWSISDSSGSGSNNSGNSQTQSQYQQHQQQLQQ 347
            ..||...|..|.                        .|:.|..|::                   
  Rat   102 PVRPPAKPPEDE------------------------PDADGYESDD------------------- 123

  Fly   348 HCRDPLLGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRT 412
             |  ..||.|:.::.|.:..::|.||:.:|:.|..||..||||||.||::: |.| :|..: .||
  Rat   124 -C--TALGTLDFSLLYDQENNALHCTISKAKGLKPMDHNGLADPYVKLHLL-PGA-SKANK-LRT 182

  Fly   413 KTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYGH-DFLGAAKVCLSTVHSTSQYRIS 476
            ||:..|.||.:||||.:.|:..|::....:.:::.|:||:.| :|:|..:|.|..:........|
  Rat   183 KTLRNTLNPSWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFS 247

  Fly   477 VPLGVEDQYS-NAAEMAQNWPNGKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQL 540
            :.|  |.|.. :.||.......|::|:||.|:::::.|:|.:.:|.:|.|||.||.|||:||..|
  Rat   248 ICL--EKQLPVDKAEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYL 310

  Fly   541 KPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASPHDLNKEMLILTVWDKDLGKSNDFLGSLQLGAQ 605
            |||..|..||||:||.:||||.:||||.:|....||.|:.|.:||||.|:||||||:|.:.||..
  Rat   311 KPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKTLEVTVWDYDIGKSNDFIGGVVLGIN 375

  Fly   606 SKGERLQQWLDCIRLPDHFHEKWHCLAPDNP 636
            :|||||:.|.||::..|...|:||.|..:.|
  Rat   376 AKGERLKHWFDCLKNKDKRIERWHTLTNEIP 406

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RphNP_572651.1 FYVE_like_SF 84..172 CDD:333710 6/18 (33%)
C2A_Rabphilin_Doc2 354..477 CDD:176000 43/123 (35%)
C2B_Rabphilin_Doc2 499..631 CDD:176030 68/131 (52%)
Doc2bNP_112404.1 Mediates interaction with DYNLT1. /evidence=ECO:0000250 1..90 17/104 (16%)
Negatively regulates targeting to plasma membrane. /evidence=ECO:0000250 1..36
PHA03247 21..>86 CDD:223021 16/72 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 38..123 28/174 (16%)
C2A_Rabphilin_Doc2 127..250 CDD:176000 44/125 (35%)
Mediates interaction with STXBP3. /evidence=ECO:0000250 257..375 59/117 (50%)
C2B_Rabphilin_Doc2 269..401 CDD:176030 68/131 (52%)
Blue background indicates that the domain is not in the aligned region.

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