DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rph and syt15

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	XP_009305102.1	Gene:	syt15 / 798021	ZFINID:	ZDB-GENE-090527-2	Length:	435	Species:	Danio rerio

Alignment Length:	530	Identity:	108/530 - (20%)
Similarity:	171/530 - (32%)	Gaps:	193/530 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 MWKKSGA-WFFKGL----PKYDMPRSASATPIPNPGPGSMAGDTRAVQSCHATPTRPARVKKLTI 204
            :|:|... .|::||    |  .:||  ..||:......|..|...:.......|.|..|..:|..
Zfish    46 LWRKRRTQTFYRGLIPATP--TIPR--CITPVLQTSQSSTYGSHGSGDVPFIVPPRFKRAPQLND 106

  Fly   205 RVNDSSSSSSGHSEPEDEVDTGVGIGVGVVGGGMAKGIASTRLQREDSFRLRAYGSIRSFIDGGE 269
            :..:|:|:......|:.....| .:.||                  ..|.|   ||||..:
Zfish   107 KKEESNSAEQWDLNPDLHSQRG-SLTVG------------------SWFPL---GSIRPDL---- 145

  Fly   270 RKLSNSFFFNRQQSQRPSECPEYDSVSMSKLRRESSFLRRGSVSSSWSISDSSGSGSNNSGNSQT 334
                      .|..:.|||                           |::.|.|...
Zfish   146 ----------YQLPEEPSE---------------------------WALPDGSAVR--------- 164

  Fly   335 QSQYQQHQQQLQQHCRDPLLGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNI-- 397
                                  |..|:.|::....|..:::||.:||..         |:.||
Zfish   165 ----------------------LWFALRYQQDKEQLVVSLLRAANLPTQ---------CQRNITL 198

  Fly   398 ----ITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLI-----YVALFD-DDKY 452
                :.|....::   ::.|...|..:|:||:|..|      ::.||.:     .::||. |.:.
Zfish   199 VKLQLLPSDDRRH---RQAKARRKGCHPQFNDTFVF------QVSNSCVDQCSLNMSLFTVDHQK 254

  Fly   453 GHDFLGAAKVCLSTVHSTSQYRISVPLGVEDQYSNAAEMAQNW------------PNGKMLLSLC 505
            .|..:|               :|.:|| :..:...||...| |            .||.:.:||.
Zfish   255 KHHLMG---------------QILIPL-ICSELKEAAGKVQ-WRDLDNESDQPLSKNGDIQVSLN 302

  Fly   506 YNTKRRALVVNV-----KQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSV---KWRTL--- 559
            ||.....|.|.|     .||.:..|:        ..|:.||  .|      |.|   ||.|:
Zfish   303 YNQSLHRLTVVVLRARGLQCCSEAAV--------CAKVCLK--IH------TQVVRNKWTTVAKG 351

  Fly   560 -NPIYNEEFYFEASPHDLNKEMLILTVWDKDLGKSNDFLGSLQLG--AQSKGERLQQWLDCIRLP 621
             :|.:||:..|...|..|:...|.|.:......|. ..|..:.:|  ..::|..|:.|.|.:..|
Zfish   352 NSPSFNEKLTFRLLPMQLDTACLSLQIQQPSTEKP-VLLAIVVIGPFMYARGRELEHWNDMVSKP 415

  Fly   622 DHFHEKWHCL 631
            .....:||.|
Zfish   416 QELVRQWHPL 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600	10/31 (32%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	27/134 (20%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	37/145 (26%)
syt15	XP_009305102.1	C2A_Synaptotagmin-15-17	164..285	CDD:176036	33/186 (18%)
syt15	XP_009305102.1	C2B_Synaptotagmin-15	294..426	CDD:176054	40/149 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000