DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rph and SYT5

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_003171.2	Gene:	SYT5 / 6861	HGNCID:	11513	Length:	386	Species:	Homo sapiens

Alignment Length:	332	Identity:	104/332 - (31%)
Similarity:	153/332 - (46%)	Gaps:	48/332 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   333 QTQSQYQQHQQQL--------------------------QQHCRDPLLGWLEIAISYREAFHSLD 371
            ::|:|.|.|.|::                          ||......||.|:.::.|......|.
Human    62 KSQAQAQVHLQEVKGLGQSYIDKVQPEVEELEPAPSGPGQQVADKHELGRLQYSLDYDFQSGQLL 126

  Fly   372 CTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEE 436
            ..:::|..|.|:|..|.:|||.::.:: |:...:|    .||...:|.||.|.||..| .|...|
Human   127 VGILQAMGLAALDLGGSSDPYVRVYLL-PDKRRRY----ETKVHRQTLNPHFGETFAF-KVPYVE 185

  Fly   437 LGNSLIYVALFDDDKYG-HDFLGAAKVCLSTVHSTSQYRISVPLGVEDQ---YSNAAEMAQNWPN 497
            ||..::.:|::|.|::. :|.:|..:|.:|          ||.||...|   ...||...:....
Human   186 LGGRVLVMAVYDFDRFSRNDAIGEVRVPMS----------SVDLGRPVQAWRELQAAPREEQEKL 240

  Fly   498 GKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPI 562
            |.:..||.|......|.|.|.:..||..||..|.|||:||:.|.....|.:|.||::|..||||.
Human   241 GDICFSLRYVPTAGKLTVIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKKKTTIKKNTLNPY 305

  Fly   563 YNEEFYFEASPHDLNKEMLILTVWDKD-LGKSNDFLGSLQLGAQSKGERLQQWLDCIRLPDHFHE 626
            |||.|.||.....:.|..:.|||.|.| ||| |:.:|.:.:||.:.|..|:.|.|.:..|.....
Human   306 YNEAFSFEVPCDQVQKVQVELTVLDYDKLGK-NEAIGRVAVGAAAGGAGLRHWADMLANPRRPIA 369

  Fly   627 KWHCLAP 633
            :||.|.|
Human   370 QWHSLRP 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	35/123 (28%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	52/132 (39%)
SYT5	NP_003171.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		C2A_Synaptotagmin-1-5-6-9-10	109..231	CDD:176031	40/137 (29%)
		C2	240..374	CDD:387358	53/134 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910