Protein Alignment Rph and Doc2a

DIOPT Version :10

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: NP_075226.1
• Gene: Doc2a / 65031
• RGDID: 620518
• Length: 403
• Species: Rattus norvegicus
• Alignment Length: 305
• Identity: 118/305 - (38%)
• Similarity: 175/305 - (57%)
• Gaps: 25/305 - (8%)

  Fly   354 LGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKT 418
            ||.||..:.|.:|...|.|.::||:.|..||..||||||.||::: |.| .|..: .:|||...|
  Rat    93 LGTLEFDLLYDQASCMLHCRILRAKGLKPMDFNGLADPYVKLHLL-PGA-CKANK-LKTKTQRNT 154

  Fly   419 RNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYGH-DFLGAAKVCLSTVHSTSQYRIS------ 476
            .||.:||.|.:.|:..:::.:.::.:::.|:||..| :|:|..:|.|..:..:.:...:
  Rat   155 LNPVWNEELTYSGITDDDITHKVLRISVCDEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQ 219

  Fly   477 VPLGVEDQYSNA----------AEMAQNWP-----NGKMLLSLCYNTKRRALVVNVKQCINLMAM 526
            |||......|.|          .|.|:..|     .|::||||.|:::|..|:|.:.:|.:|.||
  Rat   220 VPLPSPSSMSAALRGISCYLKELEQAEQGPGLLEERGRILLSLSYSSRRHGLLVGIVRCAHLAAM 284

  Fly   527 DNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASPHDLNKEMLILTVWDKDLG 591
            |.||.|||:||..|:||..|..||||.||.:||||.:||||::|.....|..:.|.:||||.|:|
  Rat   285 DVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEMELSTLATKTLEVTVWDYDIG 349

  Fly   592 KSNDFLGSLQLGAQSKGERLQQWLDCIRLPDHFHEKWHCLAPDNP 636
            |||||:|.:.||..::||..:.|.||:..||...|:||.|..:.|
  Rat   350 KSNDFIGGVSLGPGARGEAQKHWRDCLHQPDTAVERWHTLTSELP 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710
		C2A_Rabphilin_Doc2	354..477	CDD:176000	42/129 (33%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	65/131 (50%)
Doc2a	NP_075226.1	Interaction with UNC13D and DYNLT1. /evidence=ECO:0000250	1..92
		C2A_Rabphilin_Doc2	93..216	CDD:176000	42/125 (34%)
		Interaction with UNC13D. /evidence=ECO:0000250	218..403		76/177 (43%)
		C2B_Rabphilin_Doc2	257..389	CDD:176030	65/131 (50%)