DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rph and Syt4

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_113881.1	Gene:	Syt4 / 64440	RGDID:	68397	Length:	425	Species:	Rattus norvegicus

Alignment Length:	393	Identity:	103/393 - (26%)
Similarity:	170/393 - (43%)	Gaps:	58/393 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 REDSFRLRAYGSIRSFIDGGERKLSNSFFFNRQQSQRPSECPEYDSVS-----MSKLRRESSFLR 308
            :.::.|..|..::...:|..:|.|:.:|         |...|:..|.|     ..||..|:   .
  Rat    78 KSEAKRKAALPNLSLHLDLEKRDLNGNF---------PKTNPKAGSSSDLENVTPKLFPET---E 130

  Fly   309 RGSVSSSWSISDSSGSGSNNSGNSQTQSQYQQHQQQLQQHCRDPLLGWLEIAISYREAFHSLDCT 373
            :.:||..          |..|..|.|..:.|:.            ||.|.:::.|.....:....
  Rat   131 KEAVSPE----------SLKSSTSLTSEEKQEK------------LGTLFLSLEYNFEKKAFVVN 173

  Fly   374 MVRARDLPAMDAAGL-ADPYCKLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEEL 437
            :..|:.|||||...: :|||.|:.|:..:.|.     .:|:.:.||.:|.|:||..|.||....:
  Rat   174 IKEAQGLPAMDEQSMTSDPYIKMTILPEKKHK-----VKTRVLRKTLDPVFDETFTFYGVPYPHI 233

  Fly   438 GNSLIYVALFDDDKYGH-DFLGAAKVCLSTVHSTSQYRISVPLGVEDQYSNAAEMAQNWPNGKML 501
            ....::..:...|::.. |.:|...|.||.:..:....:   :..|....||.:.:   ..|::|
  Rat   234 QELSLHFTVLSFDRFSRDDVIGEVLVPLSGIELSDGKML---MTREIIKRNAKKSS---GRGELL 292

  Fly   502 LSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEE 566
            :||||.:....|.|.|.:..:|...|.:|.|||:||:.|.....:..|.||.||..|.|.::||.
  Rat   293 VSLCYQSTTNTLTVVVLKARHLPKSDVSGLSDPYVKVNLYHAKKRISKKKTHVKKCTPNAVFNEL 357

  Fly   567 FYFE---ASPHDLNKEMLILTVWDKDLGKSNDFLGSLQLGAQSKGERLQQWLDCIRLPDHFHEKW 628
            |.|:   .|..:::.|.|:|   |.:.|..|:.:|.|.|||.::|.....|.:....|.....||
  Rat   358 FVFDIPCESLEEISVEFLVL---DSERGSRNEVIGRLVLGATAEGSGGGHWKEICDFPRRQIAKW 419

  Fly   629 HCL 631
            |.|
  Rat   420 HML 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	32/124 (26%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	46/134 (34%)
Syt4	NP_113881.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	102..121		5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..147		6/33 (18%)
		C2A_Synaptotagmin-4-11	153..279	CDD:176034	33/145 (23%)
		C2B_Synaptotagmin-4	288..423	CDD:176049	48/138 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910