DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rph and Syt9

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	XP_038944965.1	Gene:	Syt9 / 60564	RGDID:	621169	Length:	566	Species:	Rattus norvegicus

Alignment Length:	444	Identity:	117/444 - (26%)
Similarity:	184/444 - (41%)	Gaps:	103/444 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 SSSSSGHSEPEDEVDTGVGIGVGVVGGGMAKGIASTRLQRE-----DSFRLRAYGSIRSFIDGGE 269
            ||....|:.|:        |.:....||......:.|:||:     .|.|   :.|||.     :
  Rat   125 SSMKISHTSPD--------IPLSTQPGGQDNCAHAVRVQRQVTEPTPSAR---HNSIRR-----Q 173

  Fly   270 RKLSNSFFFNRQQSQRPSECPEYDSVSMSKLRRESSFLRRGSVSSSWSISDSSGSGSNNSGNSQT 334
            ..|||. .||.||.||..:.     ..:.:::.|        :....|:.:..|..||:..
  Rat   174 LNLSNP-DFNIQQLQRQEQL-----TGIGRIKPE--------LYKQRSLDNDDGRRSNSKA---- 220

  Fly   335 QSQYQQHQQQLQQHCRDPLLGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIIT 399
                          |     |.|...:.|......|...:.:|.:|||.|.:|.:|||.|:.::
  Rat   221 --------------C-----GKLNFILKYDCDLEQLIVKIHKAVNLPAKDFSGTSDPYVKIYLL- 265

  Fly   400 PEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYG-HDFLGAAKVC 463
            |:..||:    :||...||.||.|:|...| .|...:|....::.:::|.|::. ||.:|..
  Rat   266 PDRKTKH----QTKVHRKTLNPVFDEVFLF-PVHYNDLEARKLHFSVYDFDRFSRHDLIGQV--- 322

  Fly   464 LSTVHSTSQYRISVPLGVEDQYSNAAEMAQN---WPN-----------GKMLLSLCYNTKRRALV 514
                             |.|.:.:.|:..:.   |.:           |:::.||||......|.
  Rat   323 -----------------VVDHFFDLADFPRECILWKDIEYVTNDNVDLGELMFSLCYLPTAGRLT 370

  Fly   515 VNVKQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASPHDLNKE 579
            :.:.:..||.|||..|:|||:||:.|..|..:.||.|||.|..||||:|||...|:..|..:::.
  Rat   371 ITIIKARNLKAMDITGASDPYVKVSLMCDGRRLKKRKTSTKRNTLNPVYNEAIVFDVPPESIDQI 435

  Fly   580 MLILTVWDKDLGKSNDFLGSLQLGAQSKGERL--QQWLDCIRLPDHFHEKWHCL 631
            .|.:.|.|.|....|:.:|..|:|  ::.|||  ..|.:.:..|......||.|
  Rat   436 HLSIAVMDYDRVGHNEVIGVCQVG--NEAERLGRDHWSEMLSYPRKPIAHWHSL 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	33/123 (27%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	48/133 (36%)
Syt9	XP_038944965.1	C2	221..345	CDD:417471	38/154 (25%)
Syt9	XP_038944965.1	C2B_Synaptotagmin-3-5-6-9-10	354..487	CDD:176048	49/134 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910