Protein Alignment Rph and Syt7

DIOPT Version :10

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: NP_001385543.1
• Gene: Syt7 / 59267
• RGDID: 62013
• Length: 687
• Species: Rattus norvegicus
• Alignment Length: 580
• Identity: 145/580 - (25%)
• Similarity: 220/580 - (37%)
• Gaps: 150/580 - (25%)

  Fly   158 PKYDMPRSASATPIPNPGPGSMA--GDTRAVQSCH----------------ATPT---------- 194
            |..|..||..|.| ..||....|  |..|.||| |                :|.|
  Rat   150 PGEDALRSGGAAP-SEPGSSGKAGRGRWRMVQS-HLAAGKLNLSNFEDSTLSTATTLESIPSSAG 212

  Fly   195 -----RPARVKKLTIRVNDSSSSSSGH--SEPEDEVDTG---------VGIGVGVVGGGMAK-GI 242
                 ||..:.:........|.:..|.  |:|......|         .|......|.|.|: |.
  Rat   213 EPKCQRPRTLMRQQSLQQPLSQNQRGRQPSQPTTSQSLGQLQAHAASAPGSNPRAYGRGQARQGT 277

  Fly   243 ASTRLQREDSFRLRA--------YGSIR-------SFIDGGERKLS-------NSFFFN------ 279
            ::....|....|.|:        .|.||       ||::|....||       ...|.|
  Rat   278 SAGSKYRAAGGRSRSNPGSWDHVVGQIRNRGLDMKSFLEGRMVVLSLVLGLSEQDDFANIPDLQN 342

  Fly   280 --RQQSQR-------------------PSECPEYDSVSMSKLRRESSFLRRGSVSSSWSISDSSG 323
              .||:|.                   |.:.|..:|...::.|...|.|.....|....:|..|
  Rat   343 PGTQQNQNAQGDKRLPAGGKAVNTAPVPGQTPHDESDRRTEPRSSVSDLVNSLTSEMLMLSPGS- 406

  Fly   324 SGSNNSGNSQTQSQYQQHQQQLQQHCRDPLLGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGL 388
                             .:.:..:.|....||.::.::.|.....:|...:::|::|||.|.:|.
  Rat   407 -----------------EEDEAHEGCSRENLGRIQFSVGYNFQESTLTVKVMKAQELPAKDFSGT 454

  Fly   389 ADPYCKLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYG 453
            :||:.|:.::..:.|.     ..||...|..||.:|||..|.|...|::...::|:.:.|.|::.
  Rat   455 SDPFVKIYLLPDKKHK-----LETKVKRKNLNPHWNETFLFEGFPYEKVVQRILYLQVLDYDRFS 514

  Fly   454 -HDFLGAAKVCLSTVHSTSQYRISVPLGVEDQYSNAAEMAQNWPN-----------GKMLLSLCY 506
             :|.:|               .:|:||...|    ..:|...|.:           |::||||||
  Rat   515 RNDPIG---------------EVSIPLNKVD----LTQMQTFWKDLKPCSDGSGSRGELLLSLCY 560

  Fly   507 NTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEA 571
            |....:::||:.:..||.|||..|:|||:||:.|.....:.:|.||..|.|.||||:||.|.|:.
  Rat   561 NPSANSIIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTKKRNLNPIFNESFAFDI 625

  Fly   572 SPHDLNKEMLILTVWDKDLGKSNDFLGSLQLGAQSKGERLQQWLDCIRLPDHFHEKWHCL 631
            ....|.:..:|:||.|||....||.:|.:.|..:|....::.|.|.|..|.....:||.|
  Rat   626 PTEKLRETTIIITVMDKDKLSRNDVIGKIYLSWKSGPGEVKHWKDMIARPRQPVAQWHQL 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710	6/13 (46%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	30/123 (24%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	52/131 (40%)
Syt7	NP_001385543.1	PHA03307	106..>311	CDD:223039	35/162 (22%)
		C2A_Synaptotagmin-7	419..543	CDD:176032	36/147 (24%)
		C2B_Synaptotagmin-7	551..686	CDD:176050	54/135 (40%)