Protein Alignment Rph and syt10

DIOPT Version :10

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: XP_017210538.3
• Gene: syt10 / 564226
• ZFINID: ZDB-GENE-041210-297
• Length: 566
• Species: Danio rerio
• Alignment Length: 493
• Identity: 125/493 - (25%)
• Similarity: 205/493 - (41%)
• Gaps: 96/493 - (19%)

  Fly   168 ATPIPNPGPGSMA--GDTRAVQSCHATPTRPARVKKLTIRVNDSSSSSSGHSEPED------EVD 224
            |.|.|.|...|::  .:.:||   .....:|::::               |.:.||      ||.
Zfish   116 APPAPPPVSRSVSPYAEAKAV---GVAGRQPSQIQ---------------HEDEEDKKWKVPEVK 162

  Fly   225 TGVGIGVGVVGGGMAKGIASTRLQREDSFRLRAYGSIRSFIDGGERKLSNSFFFNRQQSQRPSEC 289
            ......|.::...|.....|..:..|....||             .:||......||.::..|.
Zfish   163 VNGRSSVKILEAAMKISQTSPDIPAEVQQALR-------------DRLSKQAKIQRQTTEPTSS- 213

  Fly   290 PEYDSVSMSKLRRESSFLRR-------GSVSSSWSISDSSGSGSNNSGNSQTQSQYQQHQQQLQQ 347
                       .|.:||.|.       .||..:........|.:.:.|..:.: .|:|.....::
Zfish   214 -----------SRHNSFRRHLPRQMNVTSVDFTMDTLPVRQSSAVSIGRIKPE-LYKQKSVDSEE 266

  Fly   348 HCRDPL--LGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQ 410
            ..::|:  .|.|..|:||.....:|...:::|.||||.|..|.:|||.|:.:: ||...|:
Zfish   267 GTKEPVETCGKLSFALSYDYEEQALVVRILKALDLPAKDFTGTSDPYVKIYLL-PERKKKF---- 326

  Fly   411 RTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKY-GHDFLGAAKVCLSTVHSTSQYR 474
            :|:...||.||.|:|..:| .||..||.|..::.:::|.|:: .||.:|  :|.:..:.
Zfish   327 QTRVHRKTLNPTFDEDFRF-PVEYSELCNRKLHFSVYDFDRFTSHDMIG--EVVVDNLF------ 382

  Fly   475 ISVPLGVEDQYSNAAEMAQNWPN-----------GKMLLSLCYNTKRRALVVNVKQCINLMAMDN 528
                     :.|:.:..|..|.:           |:::.||||......:.:.|.:|.||.|||.
Zfish   383 ---------ELSDLSREAVVWKDILAATTESVDLGEIMYSLCYLPTAGRMTLTVIKCRNLKAMDI 438

  Fly   529 NGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASPHDLNKEMLILTVWDKDLGKS 593
            .|.|||:||:.|..|..:.||.||:.|..||||:|||...|:..|.::.:..|.:||.|.|....
Zfish   439 TGYSDPYVKVALICDGRRLKKRKTTTKKNTLNPVYNEAIIFDIPPENVEQVSLSITVMDYDRVGH 503

  Fly   594 NDFLGSLQLGAQSKGERLQQWLDCIRLPDHFHEKWHCL 631
            |:.:|..:.|..::|.....|.:.:..|......||.|
Zfish   504 NEVIGVCRAGPDAEGLGRDHWNEMLAYPRKPITHWHAL 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710	2/3 (67%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	39/123 (32%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	46/131 (35%)
syt10	XP_017210538.3	C2A_Synaptotagmin-1-5-6-9-10	274..399	CDD:176031	42/147 (29%)
		C2B_Synaptotagmin-3-5-6-9-10	408..541	CDD:176048	47/132 (36%)