Protein Alignment Rph and rph3ab

DIOPT Version :9

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: XP_691832.4
• Gene: rph3ab / 563377
• ZFINID: ZDB-GENE-090706-3
• Length: 589
• Species: Danio rerio
• Alignment Length: 639
• Identity: 212/639 - (33%)
• Similarity: 326/639 - (51%)
• Gaps: 120/639 - (18%)

  Fly    40 LRPEEQEAIISVIRRNEEIEVAERQRVGRLVERVEKIKQHAVERGPNCCRLCGDTFGILRPQRIL 104
            |..||:|.|.:||.|.|::|..|::|:||||.|::.:|:.....|.:.|.|||:..|....:.::
Zfish    23 LTDEEKEIINNVIARAEKMEAMEQERIGRLVNRLDNMKKTVCGDGVSRCLLCGEQLGGAGDRAVV 87

  Fly   105 CEDCRQSVCTKCSVDINIRYHTSERSREIWLCRICSETREMWKKSGAWFFKGLPKYDMPRSASAT 169
            ||||::::||||.|      .|:.|.|.:|||:||||.||:||:|||||||||||..:|   |..
Zfish    88 CEDCKKNMCTKCGV------QTNTRPRSVWLCKICSEQREVWKRSGAWFFKGLPKQFLP---SPM 143

  Fly   170 PIPNPGPGSMAGDTRAVQSCHATPTRPARVKKLTIRVNDSSSSSSGHSEPEDEVDTGVGIGVGVV 234
            ||..|          ..:|.|.||..|....:....|          :.||..|:..:.
Zfish   144 PISKP----------KERSPHQTPAAPPVTMQTQAPV----------TAPEPAVNPPIA------ 182

  Fly   235 GGGMAKGIASTRLQREDSFRLRAYGSIRSFIDGGERKLSNSFFFNRQQSQRPSECPEYDSVSMSK 299
                .|...:.:         .|:...:||.:.|:                |:. |:...|.|.|
Zfish   183 ----PKPPVAPK---------PAHLQTQSFSEDGD----------------PAS-PQNTPVMMKK 217

  Fly   300 LRRESSFLRRGSVSSSWSISDSSGSGSNN--------SGNSQTQSQYQQHQQQLQQHCRDP---- 352
                     ..:|.::..:|.|:.:|..:        |..|..:.:.:....::.||...|
Zfish   218 ---------TVNVHAARPVSSSTAAGLESDRGVYPPLSSGSADREELKSVSPRVAQHQNAPSVDD 273

  Fly   353 -------------LLGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHT 404
                         .||.||..:.|.:...||.|.:::|:.|..||:.||||||.||::: |.| :
Zfish   274 DDEANSYDSDEATTLGSLEFTLLYDQGNSSLHCNIIKAKGLKPMDSNGLADPYVKLHLL-PGA-S 336

  Fly   405 KYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYGH-DFLGAAKVCLS--T 466
            |.|: .||||:..||||.:||||.:.|:..|::....:.:::.|:||:|| :|:|..:|.|.  .
Zfish   337 KSTK-LRTKTLRNTRNPTWNETLVYHGLTDEDMQRKTLRLSVCDEDKFGHNEFIGETRVALKKLK 400

  Fly   467 VHSTSQYRISVPLGVEDQYSNAAEMAQN---------------WPNGKMLLSLCYNTKRRALVVN 516
            ::....:.|.:...|:.:.|:.|..|:.               ...|::|:||.|:|:...|:|.
Zfish   401 INQKKNFNICLERVVQTKRSSTAGGARGITLYEDETGKDGSELEERGRILISLMYSTQLGRLIVG 465

  Fly   517 VKQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASPHDLNKEML 581
            |.:|::|.|||.||.|||||||.||||..|..|:||.:|.:||||.:||||.:|....:|.|:.|
Zfish   466 VVRCVHLAAMDANGYSDPFVKICLKPDMGKKAKNKTQIKKKTLNPEFNEEFSYEIKHAELAKKTL 530

  Fly   582 ILTVWDKDLGKSNDFLGSLQLGAQSKGERLQQWLDCIRLPDHFHEKWHCLAPDN 635
            .::|||.|:||.||::|..|||..:|||||:.|.:|::..|...|:||.|..:|
Zfish   531 DISVWDYDIGKCNDYIGGCQLGITAKGERLKHWYECLKNKDKKIERWHTLLNEN 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600	43/87 (49%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	48/125 (38%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	66/131 (50%)
rph3ab	XP_691832.4	FYVE_RP3A	65..144	CDD:277301	42/87 (48%)
		C2A_Rabphilin_Doc2	288..411	CDD:176000	48/125 (38%)
		C2B_Rabphilin_Doc2	448..580	CDD:176030	66/131 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5199
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7921
Inparanoid	1	1.050	336	1.000	Inparanoid score	I2373
OMA	1	1.010	-	-		QHG46624
OrthoDB	1	1.010	-	-		D185575at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	1	1.000	-	-		otm24915
orthoMCL	1	0.900	-	-		OOG6_106212
Panther	1	1.100	-	-	O	PTHR45729
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.980