Protein Alignment Rph and doc2a

DIOPT Version :10

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: XP_073800319.1
• Gene: doc2a / 558815
• ZFINID: ZDB-GENE-090706-1
• Length: 486
• Species: Danio rerio
• Alignment Length: 550
• Identity: 155/550 - (28%)
• Similarity: 237/550 - (43%)
• Gaps: 138/550 - (25%)

  Fly   126 TSERSREIWLCRICSETREMWKKSGAWFFKGL--PKYDMPRSASATPIPNPGPGSMAGDTR---- 184
            :|.::..:|   |.|:.:.::.:.|.|....:  |.::...| |||...:|...|.:...|
Zfish     8 SSVKAGGLW---IESQNQLIFTEQGLWVRLRICFPLWERNYS-SATQRVSPEYNSSSMTVRKGKK 68

  Fly   185 ---------AVQSCHATPTRPAR-VKKLTIRVNDSSSSSSGHSEPEDEVDTGVGIGVGVVGGGMA 239
                     |:..|.. |.||.| :.....|::.::...|.:......:..|:|...|..||.::
Zfish    69 LTISIQEHMAIDVCPG-PIRPIRQISAYFPRLSPTAEPVSPNPASPLSLSPGLGASGGASGGLLS 132

  Fly   240 KGIASTRLQREDSFRLRAYGSIRSFIDGGERKLSNSFFFNRQQSQRPSECPEYDSVSMSKLRRES 304
            ...|..|                   .||
Zfish   133 PLQAGAR-------------------GGG------------------------------------ 142

  Fly   305 SFLRRGSVSSSWSISDSSGSGSNNSGNSQTQSQYQQHQQQLQQHCRDPLLGWLEIAISYREAFHS 369
                 |::|::.||..|....|::|.:|..                   ||.||..:.|.:|..|
Zfish   143 -----GTLSAASSIETSVDICSSDSDDSTA-------------------LGTLEFELRYEKATSS 183

  Fly   370 LDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEP 434
            |:||::||:.|..||..||||||.||::: |.| .|..: .:||||..:.||.:||||.:||:..
Zfish   184 LNCTIIRAKGLKPMDFNGLADPYVKLHLL-PGA-CKANK-LKTKTVRNSLNPVWNETLTYVGITE 245

  Fly   435 EELGNSLIYVALFDDDKYGH-DFLGAAKVCLSTVHSTSQYR----------ISVPLGVEDQYSNA 488
            |::....:.:::.|:||..| :|:|.::|.|..|......|          :..|..:.......
Zfish   246 EDMHRKTLRLSVCDEDKLTHNEFIGESRVALRRVKPDQTKRFYTCLEHPPPLPSPTAMGAALRGI 310

  Fly   489 AEMAQNWPN---------GKMLLSLCY---------NTKRRALVVNVKQCINLMAMDNNGSSDPF 535
            :...:.|.|         |::||||.:         .::|..|.|.|.:|.:|.|||.||.|||:
Zfish   311 SCYLREWENEQMTSLEERGRLLLSLQFLPPPAEGEGESRRGGLCVGVLRCAHLAAMDVNGFSDPY 375

  Fly   536 VKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASPHDLNKEMLILTVWDKDLGKSNDFLGSL 600
            |||.||||..|..||||||..:||||.:||||::|.|..:|..:.|.:||||.|||:||||:.|.
Zfish   376 VKIYLKPDVKKKSKHKTSVIKKTLNPEFNEEFFYEISLSELVHKTLEVTVWDYDLGRSNDFIDST 440

  Fly   601 QLGAQSK----GERLQQWLDCIRLPDHFHE 626
            :....|.    ...:.|.|...||  |.|:
Zfish   441 RYWKYSSEVLVHNSITQLLQMCRL--HIHD 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710	11/47 (23%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	49/133 (37%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	63/140 (45%)
doc2a	XP_073800319.1	None