Protein Alignment Rph and sytl5

DIOPT Version :10

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: XP_686619.6
• Gene: sytl5 / 558324
• ZFINID: ZDB-GENE-070912-424
• Length: 692
• Species: Danio rerio
• Alignment Length: 719
• Identity: 159/719 - (22%)
• Similarity: 281/719 - (39%)
• Gaps: 196/719 - (27%)

  Fly    40 LRPEEQEAIISVIRRNEEIEVAERQRVGRLVERVEKIKQ-----HAVERGPNCCRLCGDTFGILR 99
            |...|::.|::|::::|::...|.:|:.:|...:.::|:     .|.:|.   |.:|....|::.
Zfish    15 LLEHERQMILNVLQKDEKLRKREEKRIRKLKNELLELKRAGRRSSADQRE---CAICLRALGLIL 76

  Fly   100 PQRILCEDCRQSVCTKCSVDINIRYHTSERSREIWLCRICSETREMWKKSGAWFFK--------- 155
            .:..:|.:|::.:|..|         |:..:.....|.:|::|.|:...:|.||.:
Zfish    77 QRGNVCSNCQRRICNFC---------TATPTGSSCKCTVCAKTAELKVVTGEWFLEERSKRFQSA 132

  Fly   156 GLPKYDMPRSASATPIPNPGPGSMAGDTRAVQSCHATPTRPARVKKLTIRVNDSSSSSSGHS-EP 219
            .:|..|:.:.:..:..|:.|                :..||..:::       ||:..|..| .|
Zfish   133 TVPSCDVVKQSILSSPPDGG----------------SANRPLEMER-------SSTPKSERSVTP 174

  Fly   220 EDEVDTG--------VGI---GVGVVGGGMAKGIASTRLQREDSFR---------LRAYGSIRSF 264
            :.:..||        |.:   |:..|...|...:|.|..|.|...|         :::..|:...
Zfish   175 QSQKSTGKNRKGKRAVAVEPSGLPTVPNNMRAQMAKTPTQTEARNRPDGAESVSSIQSSDSVPEK 239

  Fly   265 IDGGERKLSN----------SFFFNRQQSQ----RPSE----------C------------PEYD 293
            :..|.|:..:          |...:|.:|:    .|.|          |            .:.|
Zfish   240 MADGRRQTDSSTPSIAVSRASLSSDRSRSEVDLSNPGEGLSEDPLISRCRSVPGLNDGDSDEDID 304

  Fly   294 SVSMSKLRRESSFLRRGSVSSS------WSISDSSGSGSNNSGNSQTQSQYQQHQQQLQQHCRDP 352
            :|..:..:...|.....|:||:      |...:...|.::.:..:...|.|.:............
Zfish   305 AVLSAHYKTNRSVCSAQSMSSTPASERKWGFLNVPDSDADTTSINSLMSVYSETGDYGSVRVSGE 369

  Fly   353 LLGWLEIAISYRE-AFHSL--DCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKT 414
            :|  |.|:.||:. |.:.|  :|..:...|    :.....|.|.|..::..:     :|..:.||
Zfish   370 IL--LNISYSYKTGALNVLVRECRCLATGD----ERRQRTDAYVKTYLLPDK-----SRQSKRKT 423

  Fly   415 VHKTR--NPEFNETLQFVGVEPEELGNSLIYVALFDDDKYGH-DFLGAAKVCLST---------- 466
            ..|:.  ||.|||.|::| |...:|....:.|:::..|::|| :|||..::...:
Zfish   424 SIKSNSTNPVFNENLRYV-VSHSQLETRTLQVSVWHHDRFGHNNFLGETELTFDSWEFDTQIEEW 487

  Fly   467 -----------VHSTSQYR---------------ISVPLG---VEDQYSNAAEMAQNWPNGKMLL 502
                       |.|...|:               :|:||.   |:..:....:.....|.|.|:.
Zfish   488 FALQPRIESDYVDSVMHYKGELTVVLKYIPAERNVSLPLDQVQVKKGFLKGKKKTITLPKGGMVE 552

  Fly   503 SLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEF 567
            .|            ||:..||.|: ..||||||||..|.||..|:.||||:|..|::||.:|..|
Zfish   553 LL------------VKEAKNLTAV-KGGSSDPFVKGYLLPDDKKSTKHKTAVVKRSVNPRWNHTF 604

  Fly   568 YFEASPH-DLNKEMLILTVWDKDLGKSNDFLGSLQLGA-------------QSKGERLQQWLDCI 618
            .:....| ||:...|.|||||::...||.|||.::|||             .:.||..:.|...|
Zfish   605 TYCGLQHSDLDSVCLELTVWDREPFASNVFLGGVRLGAGTGLSYGKEVDWNDAYGEEQRLWQRMI 669

  Fly   619 RLPD 622
            ..|:
Zfish   670 DNPE 673

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710	17/96 (18%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	35/164 (21%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	51/138 (37%)
sytl5	XP_686619.6	PHD_SF	13..124	CDD:473978	26/120 (22%)
		PHA03247	<132..401	CDD:223021	50/297 (17%)
		C2A_SLP-4_5	367..491	CDD:175995	32/135 (24%)
		C2B_SLP_1-2-3-4	506..683	CDD:175987	57/181 (31%)