DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rph and syt5b

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_001018382.2	Gene:	syt5b / 553567	ZFINID:	ZDB-GENE-050522-134	Length:	446	Species:	Danio rerio

Alignment Length:	338	Identity:	107/338 - (31%)
Similarity:	165/338 - (48%)	Gaps:	27/338 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 SKLRRESSFLRRGSVSSSWSISDSSGSGSNNSGNSQTQSQYQQHQQQLQQHCRDPLLGWLEIAIS 362
            ||..||.....|..|         .|:.....|..:.:.:.::.::|.::|   ..||.||.::.
Zfish   123 SKKARERKRAARKKV---------EGTEGEGQGEQKDEGEKKEGEEQKEEH---ENLGKLEFSLD 175

  Fly   363 YREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETL 427
            |......|...:::|:||.|||..|.:|||.|:.:: |:...|:    .||...|...|.||||.
Zfish   176 YNFTDAQLIVGILQAQDLAAMDIGGTSDPYVKVYLL-PDKKKKF----ETKVQRKNLCPVFNETF 235

  Fly   428 QFVGVEPEELGNSLIYVALFDDDKYG-HDFLGAAKVCLSTVHSTSQYRISVPLGVEDQYSNAAEM 491
            .| .:...|||...:.:.:||.|::| ||.:|..|:.::.|.      ::.||....:..|..:.
Zfish   236 IF-KIPYAELGGKTLVLQVFDFDRFGKHDVIGQIKIPMNCVD------LAQPLHEWRELENGEKE 293

  Fly   492 AQNWPNGKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKW 556
            .:..  |.:.:||.|......|.||:.:..||..||..|.|||:|||.|:.:..:.||.||:||.
Zfish   294 EEKL--GDVCISLRYVPTAGKLTVNIMEAKNLKKMDVGGLSDPYVKIVLQHNGKRLKKKKTTVKK 356

  Fly   557 RTLNPIYNEEFYFEASPHDLNKEMLILTVWDKDLGKSNDFLGSLQLGAQSKGERLQQWLDCIRLP 621
            .||||.:||.|.||.....:.|..|::||:|.|...|||.:|...:|..:.|..|:.|.|.:..|
Zfish   357 NTLNPYFNESFSFEVPFEQIQKVQLLITVYDYDKLGSNDPIGKTFIGYGATGVGLRHWSDMLANP 421

  Fly   622 DHFHEKWHCLAPD 634
            .....:||.|.|:
Zfish   422 RRPVAQWHTLQPE 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	40/123 (33%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	51/131 (39%)
syt5b	NP_001018382.2	C2A_Synaptotagmin-1-5-6-9-10	166..285	CDD:176031	42/130 (32%)
syt5b	NP_001018382.2	C2B_Synaptotagmin-1	298..432	CDD:176047	52/133 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910