Protein Alignment Rph and sytl4

DIOPT Version :10

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: NP_001074457.1
• Gene: sytl4 / 553322
• ZFINID: ZDB-GENE-070209-217
• Length: 689
• Species: Danio rerio
• Alignment Length: 739
• Identity: 170/739 - (23%)
• Similarity: 267/739 - (36%)
• Gaps: 226/739 - (30%)

  Fly    40 LRPEEQEAIISVIRRNEEIEVAERQRVGRLVERVEKIKQHAVERG-----PNCCRLCGDTFGILR 99
            |...|||.|:.|:||:|::...|..||.:|......|::...:||     ...|..|.:...:|.
Zfish    12 LTDSEQEFILEVLRRDEDLRHLEDLRVKKLKAEFLDIRRKGAKRGSGKYSERSCGRCQEPLSLLS 76

  Fly   100 PQRILCEDCRQSVCTKCSVDINIRYHTSERSREIWLCRICSETREMWKKSGAWF-------FKGL 157
            .....|..|:..||.||.         |.|....|:|.:|::..::...:|.||       |...
Zfish    77 GSGSQCRSCKHQVCKKCQ---------SVRPNGSWVCTVCAKEIDLKMSTGDWFFDERVNRFSSA 132

  Fly   158 PKYDMPR--------------------------SASATPIPNP---------------GPGSMAG 181
            |.:|:.|                          ::.|.|:|.|               |......
Zfish   133 PGHDLVRVSLRKRPLSKKHETAGEILLNKVELNTSQAAPVPKPRLKDIALANKSSLLEGEEGQQS 197

  Fly   182 DTRAVQ-----SCHA----TPTRPARVKKLTIRVNDSSSSSSGHSEPEDEVDTGVGIGVGVVGGG 237
            ||.:::     |.||    :.:.|...:|..:|.|          .||   |..|.|.:..|...
Zfish   198 DTESIEKASLDSDHAETKFSHSTPQMQRKEELRAN----------SPE---DCAVSILMSTVNSD 249

  Fly   238 MAKGIASTRLQR-----EDSFRLRAYGSIRSFIDGGERKLSNSFFFNRQQSQRPSECPEYDSVSM 297
            ....|.:..|..     .||.|         .:||          ..::..:|..:..|....|.
Zfish   250 STATIETASLIHHMNACSDSLR---------DVDG----------LFKKSVRRVHKLSEIKPAST 295

  Fly   298 SKLRRESSFLRRGSVSSSWSISDSS----------------------------GSGSNNSGNSQT 334
            ..||.::      |.:::.|:.|.|                            ||...:.|.|:|
Zfish   296 LDLREDA------SENTTPSMGDRSKSVPGLNADDDEEEEDIDNLVNIHRQKFGSSMGSLGGSRT 354

  Fly   335 -----QSQYQQ-----HQQQLQQHCRDPLLGWLEIAISYREAFHSLDCTMVRARDLPAMD-AAGL 388
                 .|.|.:     |.:         :.|.:..::||.|...||...:...:.|...| |...
Zfish   355 TLGSMMSVYSEAGDYDHVE---------VSGEIVFSLSYDEPSQSLSVMVHECKGLAYADPAKKK 410

  Fly   389 ADPYCKLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYG 453
            .:||.|..:: |:...|     :|...|...||.|.|||:: .:...:|....:.::::..|::|
Zfish   411 CNPYVKAYLL-PDKSKK-----KTSIKHNNINPSFKETLKY-SISRTQLMTRTLQLSVWHYDRFG 468

  Fly   454 HD-FLGAAKVCLSTVHSTSQYR-------ISVP---LGVEDQYSNAAEMAQNWPNGKMLLSLCYN 507
            |: |||..:|.:.:....|.:.       .:||   |...|||           .|::::||.|.
Zfish   469 HNAFLGEVEVLMDSYDIDSAHEECMALRGKAVPQSLLSPFDQY-----------KGELVISLKYV 522

  Fly   508 TKR-------------------RALVVNVKQCINLMAMDNNGSSDPFVKIQLKPDAHK-NKKHKT 552
            |..                   ..|.|.:|:..||.|:...|:.|.|||..|.|...| :.|.||
Zfish   523 TPNAPNAEDSKGKGKKSKPADGSELHVLIKEAKNLTALKAGGTCDSFVKGYLLPSKSKSSSKKKT 587

  Fly   553 SVKWRTLNPIYNEEFYFEASPHDLNKEM-LILTVWDKDLGKSNDFLGSLQLG------------- 603
            .|..:|.:|.||..|.:.....|..|:| |.|||||::...||||||.::|.
Zfish   588 PVVKKTKSPNYNHTFVYNNLSLDELKDMCLELTVWDRETLSSNDFLGGVRLSLGAVTVKEGKEEW 652

  Fly   604 -AQSKGERLQQWLDCIRLPDHFHE 626
             |.|.||.:..|...::.||.:.|
Zfish   653 MADSTGEEILLWKKMMQYPDSWAE 676

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710	24/125 (19%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	31/131 (24%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	51/163 (31%)
sytl4	NP_001074457.1	PHD_SF	10..124	CDD:473978	33/120 (28%)
		FYVE_Slp4	60..109	CDD:277303	14/57 (25%)
		C2A_SLP-4_5	375..496	CDD:175995	31/127 (24%)
		C2B_SLP_1-2-3-4	512..682	CDD:175987	52/165 (32%)