DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rph and Syt10

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_061273.1	Gene:	Syt10 / 54526	MGIID:	1859546	Length:	523	Species:	Mus musculus

Alignment Length:	377	Identity:	103/377 - (27%)
Similarity:	177/377 - (46%)	Gaps:	62/377 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   280 RQQSQRPSECPEYDSVSMSKLRRESSFLRRGSVSSSWSISDSSGS------GSNNSGNSQTQSQ- 337
            ::|:..|:....::|     .||.  ..|:.:||   |:..|.|:      |...:...:.:.:
Mouse   159 QRQTTEPTSSSRHNS-----FRRH--LPRQMNVS---SVDFSVGTEPILQRGETRTSIGRIKPEL 213

  Fly   338 YQQHQQQLQQHCRDPL--LGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITP 400
            |:|.....:.:.:|.:  .|.|..|:.|......|...:::|.||||.|..|.:|||.|:.:: |
Mouse   214 YKQKSVDSEGNRKDDVKTCGKLNFALQYDYENELLVVKIIKALDLPAKDFTGTSDPYVKIYLL-P 277

  Fly   401 EAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYG-HDFLGAAKVCL 464
            :...|:    :|:...||.||.|:|..|| .|..::|.|..::.:::|.|::. ||.:|  :|.|
Mouse   278 DRKKKF----QTRVHRKTLNPLFDELFQF-PVVYDQLSNRKLHFSIYDFDRFSRHDMIG--EVIL 335

  Fly   465 STVHSTSQYRISVPLGVEDQYSNAAEMAQNWPN-----------GKMLLSLCYNTKRRALVVNVK 518
            ..:.               :.|:.:..|..|.:           |:::.||||......:.:.|.
Mouse   336 DNLF---------------EVSDLSREATVWKDIHCATTESIDLGEIMFSLCYLPTAGRMTLTVI 385

  Fly   519 QCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASPHDLNKEMLIL 583
            :|.||.|||..|||||:||:.|..:..:.||.||:.|..||||:|||...|:..|.::::..|.:
Mouse   386 KCRNLKAMDITGSSDPYVKVSLMCEGRRLKKRKTTTKKNTLNPVYNEAIIFDIPPENVDQVSLCI 450

  Fly   584 TVWDKDLGKSNDFLGSLQLGAQSKGERLQQWLDCIRLPDHFHEK----WHCL 631
            .|.|.|....|:.:|..:.|..::|.....|.:.:.    :|.|    ||.|
Mouse   451 AVMDYDRVGHNEVIGVCRTGLDAEGLGRDHWNEMLA----YHRKPITHWHPL 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	37/123 (30%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	46/135 (34%)
Syt10	NP_061273.1	Cysteine motif. /evidence=ECO:0000250\|UniProtKB:O35681	13..35
		C2A_Synaptotagmin-1-5-6-9-10	231..356	CDD:176031	40/147 (27%)
		C2B_Synaptotagmin-3-5-6-9-10	365..498	CDD:176048	47/136 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910