DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rph and Syt6

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	XP_006501767.1	Gene:	Syt6 / 54524	MGIID:	1859544	Length:	529	Species:	Mus musculus

Alignment Length:	512	Identity:	124/512 - (24%)
Similarity:	211/512 - (41%)	Gaps:	128/512 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 WKKSGAWFFKGLPKYDMPRSA--SATPIPNPGP-GSMAGDTR----------AVQSCHATPTRPA 197
            |:|..|         ..|.||  ::..:.:|.. |:||...:          ||:..|.:|..||
Mouse    88 WRKKEA---------SSPSSANPASETLQSPSSRGNMADKLKDPSALGFLEAAVKISHTSPDIPA 143

  Fly   198 RVK-----------KLTIRVNDSSSSSSGHSEPEDEVDTGVGIGVGVVGGGMAKGIASTRLQRED 251
            .|:           ||..:..:.:||:                                   |..
Mouse   144 EVQMSVKEHIMRHTKLQRQTTEPASST-----------------------------------RHT 173

  Fly   252 SFRLRAYGSIR-SFIDGGERKLSNSFFFNRQQSQRPSECPEYDSVSMSKLRRESSFLRRGSVSSS 315
            ||:......:. |.:|.|              ::.|....| ...|:.:::.|  ..::.||...
Mouse   174 SFKRHLPRQMHVSSVDYG--------------NELPPAAAE-QPTSIGRIKPE--LYKQKSVDGD 221

  Fly   316 WSISDSSGSGSNNSGNSQTQSQYQQHQQQLQQHCRDPLLGWLEIAISYREAFHSLDCTMVRARDL 380
            .:.|:::.|                        |     |.:..::.|.....:|...:::|.||
Mouse   222 DAKSEAAKS------------------------C-----GKINFSLRYDYESETLIVRILKAFDL 257

  Fly   381 PAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVA 445
            ||.|..|.:|||.|:.:: |:...|.    :|:...||.||.|:|...| .|..|||.:..::::
Mouse   258 PAKDFCGSSDPYVKIYLL-PDRKCKL----QTRVHRKTLNPTFDENFHF-PVPYEELADRKLHLS 316

  Fly   446 LFDDDKYG-HDFLGAAKVCLSTVHSTSQYRISVPLGVEDQYSNAAEMAQNWPNGKMLLSLCYNTK 509
            :||.|::. ||.:|  :|.|..:...|.......:..:.||:.    :::...|:::.||||...
Mouse   317 VFDFDRFSRHDMIG--EVILDNLFEASDLSRETSIWKDIQYAT----SESVDLGEIMFSLCYLPT 375

  Fly   510 RRALVVNVKQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASPH 574
            ...|.:.|.:|.||.|||..|.|||:||:.|..|..:.||.||::|..||||||||...|:..|.
Mouse   376 AGRLTLTVIKCRNLKAMDITGYSDPYVKVSLLCDGRRLKKKKTTIKKNTLNPIYNEAIIFDIPPE 440

  Fly   575 DLNKEMLILTVWDKDLGKSNDFLGSLQLGAQSKGERLQQWLDCIRLPDHFHEKWHCL 631
            ::::..|:::|.|.|....|:.:|..::|..::|.....|.:.:..|......||.|
Mouse   441 NMDQVSLLISVMDYDRVGHNEIIGVCRVGINAEGLGRDHWNEMLAYPRKPIAHWHSL 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600	6/27 (22%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	37/123 (30%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	47/131 (36%)
Syt6	XP_006501767.1	C2A_Synaptotagmin-1-5-6-9-10	231..355	CDD:176031	38/136 (28%)
Syt6	XP_006501767.1	C2B_Synaptotagmin-3-5-6-9-10	364..497	CDD:176048	48/132 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910