Protein Alignment Rph and SYT17

DIOPT Version :10

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: XP_047290159.1
• Gene: SYT17 / 51760
• HGNCID: 24119
• Length: 500
• Species: Homo sapiens
• Alignment Length: 599
• Identity: 143/599 - (23%)
• Similarity: 208/599 - (34%)
• Gaps: 200/599 - (33%)

  Fly    92 GDTFGILRPQR----------ILCE-DCRQSVCTKCSVDINIRYHTSERSREIWLCRICSETREM 145
            |..||.|.|..          :||. .||. .|.||       |.:|           |.::.|
Human    26 GAAFGQLEPLNEGFLSRISGLLLCRWTCRH-CCQKC-------YESS-----------CCQSSE- 70

  Fly   146 WKKSGAWFFKGLPKYDMPRSASATPIPNPGPGSMA-------GDTRAVQSCHATPTRPARVKKLT 203
                           |........|...| |..||       ||     |.|.....|     ||
Human    71 ---------------DEVEILGPFPAQTP-PWLMASRSSDKDGD-----SVHTASEVP-----LT 109

  Fly   204 IRVN--DSSSSSSGHSEPEDEVDTGVGIGVGVVGGGMAKGIASTRLQREDSFRLRAYGSIRSFID 266
            .|.|  |...|||         ||.                       :.::.|
Human   110 PRTNSPDGRRSSS---------DTS-----------------------KSTYSL----------- 131

  Fly   267 GGERKLSNSFFFNRQQSQRPSECP-------EYDSVSMSKLRRESSFLRRGSVSSS--------- 315
              .|::|:      .:|:|||. |       |:..:|..|...:.|.|||......
Human   132 --TRRISS------LESRRPSS-PLIDIKPIEFGVLSAKKEPIQPSVLRRTYNPDDYFRKFEPHL 187

  Fly   316 WSISDSSGSGSNNSGNSQTQSQYQQHQQQLQQHCRDPLLGWLEIAISYREAFHSLDCTMVRARDL 380
            :|: ||:....::..:.:..|:||              ||.|..:..|....:.|...::.||||
Human   188 YSL-DSNSDDVDSLTDEEILSKYQ--------------LGMLHFSTQYDLLHNHLTVRVIEARDL 237

  Fly   381 P--------AMDAAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEEL 437
            |        ..|.|. ::||.|:.::..:.::|.|..:|     ||:.|.|.|...| .:...|.
Human   238 PPPISHDGSRQDMAH-SNPYVKICLLPDQKNSKQTGVKR-----KTQKPVFEERYTF-EIPFLEA 295

  Fly   438 GNSLIYVALFDDDKYG-HDFLGAAKVCLSTVHSTSQYRISVPLGVED-------------QYSNA 488
            ....:.:.:.|.||:. |..:|               ::||||...|             ...|.
Human   296 QRRTLLLTVVDFDKFSRHCVIG---------------KVSVPLCEVDLVKGGHWWKALIPSSQNE 345

  Fly   489 AEMAQNWPNGKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTS 553
            .|:      |::||||.|......|.|:|.:...|:..|.:..|||||||||.......|..|||
Human   346 VEL------GELLLSLNYLPSAGRLNVDVIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTKKTS 404

  Fly   554 VKWRTLNPIYNEEFYFEASPHDLNKEMLILTVWDKDLGKSNDFLGSLQLGAQSKG-ERLQQWLDC 617
            ....|::|.|||.|.|:....:|....|:.||:..::..||||:|.:.:|..|.| .....|...
Human   405 FLRGTIDPFYNESFSFKVPQEELENASLVFTVFGHNMKSSNDFIGRIVIGQYSSGPSETNHWRRM 469

  Fly   618 IRLPDHFHEKWHCL 631
            :.......|:||.|
Human   470 LNTHRTAVEQWHSL 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710	18/90 (20%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	30/131 (23%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	46/132 (35%)
SYT17	XP_047290159.1	C2A_Synaptotagmin-15-17	212..340	CDD:176036	34/149 (23%)
		C2B_Synaptotagmin-17	349..483	CDD:176055	47/133 (35%)