Protein Alignment Rph and sytl2

DIOPT Version :10

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: XP_012812257.2
• Gene: sytl2 / 493264
• XenbaseID: XB-GENE-945155
• Length: 2036
• Species: Xenopus tropicalis
• Alignment Length: 695
• Identity: 150/695 - (21%)
• Similarity: 260/695 - (37%)
• Gaps: 188/695 - (27%)

  Fly    20 QLALRAKLK---AGWSSSKTSEPLRPEEQEAIISVIRRNEEI--EVAERQRVGRLVERVEKIKQH 79
            ||..:..||   :..||:||:..|...::        |:|.:  :::.|:             ..
 Frog  1396 QLKTKDNLKDNLSDTSSTKTASTLNDLQE--------RDENVYKDISSRE-------------SS 1439

  Fly    80 AVERGPNCCRLCGDTFGILRPQRILCEDCRQSVCTKCSVDINIRYHTSER---SREIWLCRICSE 141
            :|: |.:.. :.||..|                  |.:..:::..||.|.   :|| |      .
 Frog  1440 SVD-GASAA-VIGDIIG------------------KDAASLDLHQHTDEEEIGARE-W------N 1477

  Fly   142 TREMWKKSGAWFFKGLPKYDMPRS------ASATPIPNPGPGSMAGDTRAVQSCHATPTRP---- 196
            ..|...:....|...:|..|:..|      ..:.|.......::...|...:....|..:|
 Frog  1478 WEEPESQDNPTFISNMPSRDVVISKKVYSTIESLPSYKDKENNLDRLTEPQEQGSTTQRKPQDLY 1542

  Fly   197 --ARVKKLTIRVNDSSSSSSG----------HSEPEDE---------VDTGVGIG-----VGVVG 235
              ||.:.|.   .:|.|..||          :.:||.|         :|...||.     :..:.
 Frog  1543 FAARYEVLD---KNSGSDQSGSVTESSGNLLYKKPESESPDASKRNSIDPKQGIEESDPILRALK 1604

  Fly   236 GGMAKGIASTRLQ---------------REDSFRLRAYGSIRS---------FIDGGE-RKLSNS 275
            ....|.:....:|               :||  |...|..:|:         |.|..: ::||.|
 Frog  1605 RSSTKTLPPLPVQEVSLEKSNQDDITVPKED--RDHTYEEVRADKVVPERSHFSDPEKLKRLSQS 1667

  Fly   276 F--FFNRQQSQRPSECPEYDSVSMSKLRRESSF---LRRGSVSSSWSISDSSGSGSNNSGNSQTQ 335
            .  |.|.....|     |.||.|      ||||   ..:.|.||..::|.|||..|.:|.:....
 Frog  1668 VPSFLNDDTDGR-----ETDSAS------ESSFQLGRHKKSPSSLTNLSGSSGMASLSSVSGSVM 1721

  Fly   336 SQYQQHQQQLQQHCRDPLLGWLEIAISYREAFHSLDCTMVRARDLPAMDA-AGLADPYCKLNIIT 399
            |.|......:.      :.|.::.|:.|.:........:.:.:||.|.|. ...:|||.|..::.
 Frog  1722 SIYSGDFGNVD------IKGNIQFALDYADNLQEFQVFVSQCKDLAAADVKKQRSDPYVKAYLLP 1780

  Fly   400 PEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYG-HDFLGAAKVC 463
            .:|  |..: ::|....||.||.:|:.|:: .:....|.:..:.::::..|..| :.|||...|.
 Frog  1781 EKA--KMGK-RKTGVKKKTLNPVYNDVLRY-KISKNALLSQTLNLSVWHHDVLGRNSFLGEVDVN 1841

  Fly   464 LSTVHSTSQYRISVPL---------GVEDQYSNAAEMAQNWPNGKMLLSLCY---------NTKR 510
            |::...:::.....||         |:|::             |:|.|:|.|         |...
 Frog  1842 LASWDWSNKQMNWYPLQPRTPAAGIGLENR-------------GEMKLALKYVPEAFTGAKNAGT 1893

  Fly   511 RALVVNVKQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEA-SPH 574
            ..:.:.:|:|.||..:..| ..:.|:|..:.||..:..:.||....:|.||.:|....::. ...
 Frog  1894 GEVHIWLKECTNLPMLRGN-KINSFIKCTILPDTSRKSRQKTRAVDKTPNPYFNHTMVYDGFRKE 1957

  Fly   575 DLNKEMLILTVWDKDLGKSNDFLGSLQLG---AQSKGERLQQWLD 616
            ||.:..:.|||||.: ..:|.|||.|::|   .:|.|..: .|:|
 Frog  1958 DLKEACVELTVWDHN-KLTNHFLGGLRIGLGTGKSYGTPV-DWMD 2000

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710	17/96 (18%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	28/124 (23%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	37/131 (28%)
sytl2	XP_012812257.2	PHD_SF	5..>44	CDD:473978
		C2A_SLP-1_2	1734..1858	CDD:176039	29/127 (23%)
		C2B_SLP_1-2-3-4	1871..2027	CDD:175987	38/146 (26%)