Protein Alignment Rph and sytl1

DIOPT Version :10

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: NP_001006773.1
• Gene: sytl1 / 448459
• XenbaseID: XB-GENE-972182
• Length: 518
• Species: Xenopus tropicalis
• Alignment Length: 613
• Identity: 136/613 - (22%)
• Similarity: 216/613 - (35%)
• Gaps: 185/613 - (30%)

  Fly    40 LRPEEQEAIISVIRRNEEIEVAERQRVGRLVERVEKIKQHAVERGPNCCRLCGDTFGILRPQR-- 102
            |..|||..|:.|:.|:.|::..|.||:.:|...:...|...        ||.|:.|..:|..|
 Frog    22 LTGEEQLMIVQVLERDTELKAKEDQRIKKLRSTLPDKKAFK--------RLSGEWFCDVRATRPW 78

  Fly   103 -------ILCEDCRQSVCTKCSVDINIRYHTSERSREIWLCRICSETREMWKKSGAWFFKGLPKY 160
                   |:....|:....:...|||  :...|           :|.||
 Frog    79 GQTGGVDIVRASIRRKKKVRGECDIN--WDQDE-----------NEERE---------------- 114

  Fly   161 DMPRSASATPIPNPGPGSMAGDTRAVQSCHATPTRPARVKKLTIRVNDSSSSSSGHSEPEDEVDT 225
                          ||.......: :.|..:.|.|      |:....|.|||.      ||
 Frog   115 --------------GPEETCAPVK-ISSSESLPDR------LSSDAQDWSSSK------ED---- 148

  Fly   226 GVGIGVGVVGGGMAKGIASTRLQREDSFRLRAYGSIRSFIDGGERKLSNSFFFNRQQSQRPSECP 290
                    |||....|    :...||.......|:|.|....||      ....::........|
 Frog   149 --------VGGDTTDG----KNSMEDINLSPVNGTITSGDTNGE------ILEGKENLNDSPPVP 195

  Fly   291 EYDSVSMSKLRRESSFLRRGSVSSSWSISDSSGSGSNNSGNSQTQSQYQQHQQQLQQHCRDPLLG 355
            ...:.|:|           ||:.|.:|      :|...|.:.|                     |
 Frog   196 RLTNNSIS-----------GSMISLFS------TGDMRSVDVQ---------------------G 222

  Fly   356 WLEIAISYREAFHSLDCTMVRARDL-PAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKTR 419
            .::.::.|..:...|:..:::.||| ||....  ::||.|..:: |:...:..|  ::|...||.
 Frog   223 CVQFSLQYDPSKKELNVLIIQCRDLTPAQRKT--SNPYIKCYLL-PDKTVQGKR--KSKVKKKTL 282

  Fly   420 NPEFNETLQFVGVEPEELGNSLIYVALFDDDKYGHD-FLGAAKV--------------------- 462
            .|.|||||:: .||..||.:.::.::::.....|.: |||..:|
 Frog   283 EPFFNETLKY-KVERSELQSRVLNLSVWHRGSLGRNIFLGEVEVDLVSWDWSKTQPSWFNLQPRT 346

  Fly   463 CLSTVHSTSQYRISVPLGVEDQYSNAAEMAQNWPNGKMLLSLCYNTKRRALVVNVKQCINLMAMD 527
            .||.....|:.||||.|....|   .||.....|.|:             |.|.:|:...|:. .
 Frog   347 PLSPDFLCSRGRISVALKYVPQ---GAEGLGLPPTGE-------------LHVWIKEARQLVP-H 394

  Fly   528 NNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEA-SPHDLNKEMLILTVWDKDLG 591
            ..|:...|||..:.||:..:....|.|...:|:|::|....::. |..||.:..:..|:||:  |
 Frog   395 KAGNVSTFVKCFVLPDSVPSNFQNTRVIPHSLHPMFNHTMVYDGFSGEDLKEACVECTIWDQ--G 457

  Fly   592 K-SNDFLGSLQL--GAQSKGERLQQWLD 616
            | .:..||.::|  |..|..|....|:|
 Frog   458 KIGSRSLGGIRLSTGKGSSYETSVSWMD 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710	15/96 (16%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	36/145 (25%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	31/122 (25%)
sytl1	NP_001006773.1	PHD_SF	20..>66	CDD:473978	15/51 (29%)
		C2	221..343	CDD:472691	32/148 (22%)
		C2B_SLP_1-2-3-4	356..512	CDD:175987	41/149 (28%)