DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rph and syt9b

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_001003985.1	Gene:	syt9b / 445476	ZFINID:	ZDB-GENE-040822-6	Length:	517	Species:	Danio rerio

Alignment Length:	404	Identity:	106/404 - (26%)
Similarity:	176/404 - (43%)	Gaps:	53/404 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 IDGGERKLSNSFFFNRQ-------------------QSQRPSECPEYDSVSMSKLRRE----SSF 306
            ::|.||:.|..|..:..                   |.:..::..|.:.:.:::::|:    :|.
Zfish   105 VEGLEREYSEDFEKDPNAPLVLPESAMKISHTSPDIQLEAQTKAKELNHIHIARVQRQVTEPTSS 169

  Fly   307 LRRGSVSSSWSISDSSGSGSNNSGNSQTQSQ-------------YQQHQQQLQQHCRDPLLGWLE 358
            :|..|:....::|:.    ..|....|.|..             |:|.........|....|.|.
Zfish   170 VRHNSIRRQMNVSNP----DFNMAQFQRQESITGPGLGRIKPELYKQRSVDTDDGRRADSCGRLH 230

  Fly   359 IAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKTRNPEF 423
            ..|.|......|...:.||:||||.|..|.:|||.|:.:: |:..||:    :||...||.||.|
Zfish   231 FIIKYDCDLEQLIVKIHRAQDLPAKDFTGTSDPYVKIYLL-PDRKTKH----QTKVHRKTLNPIF 290

  Fly   424 NETLQFVGVEPEELGNSLIYVALFDDDKYG-HDFLGAAKVCLSTVHSTSQYRISVPLGVEDQYSN 487
            :|...| .|...||....::.:::|.|::. ||.:|  :|.:........:.....|..:..|.:
Zfish   291 DEVFLF-PVAYGELPTRKLHFSVYDFDRFSRHDVIG--QVVVDNFLDLPDFPQETRLCRDILYVS 352

  Fly   488 AAEMAQNWPNGKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKT 552
                |.|...|.::.||||......|.:.:.:..||.|||..|:|||:||:.|..|..:.||.||
Zfish   353 ----ADNVDLGDLMFSLCYLPTAGRLTITIIKARNLKAMDITGASDPYVKVSLMCDGRRLKKRKT 413

  Fly   553 SVKWRTLNPIYNEEFYFEASPHDLNKEMLILTVWDKDLGKSNDFLGSLQLGAQSKGERLQQWLDC 617
            |.|..||||:|||...|:..|.::::..|::.|.|.|....|:.:|...:|.::.......|.:.
Zfish   414 STKRNTLNPVYNEAIVFDVPPENIDQISLLIAVMDYDRVGHNEVIGICHVGNRAPSLGRDHWNEM 478

  Fly   618 IRLPDHFHEKWHCL 631
            :..|.....:||.|
Zfish   479 LTYPRKPIARWHQL 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	38/123 (31%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	44/131 (34%)
syt9b	NP_001003985.1	C2	226..350	CDD:301316	39/131 (30%)
syt9b	NP_001003985.1	C2B_Synaptotagmin-3-5-6-9-10	359..492	CDD:176048	45/132 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910