DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rph and syt1a

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_001314758.1	Gene:	syt1a / 436736	ZFINID:	ZDB-GENE-040718-165	Length:	419	Species:	Danio rerio

Alignment Length:	311	Identity:	104/311 - (33%)
Similarity:	158/311 - (50%)	Gaps:	30/311 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   329 SGNSQTQSQYQQHQQQLQQHCRDPLLGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYC 393
            :|.:.|:.:.:..:::        .||.|:.::.|....::|...:::|.:|||||..|.:|||.
Zfish   122 TGLTDTEKEVEPKEEE--------KLGKLQYSMDYNFTENTLIVGIIQAAELPAMDMGGTSDPYV 178

  Fly   394 KLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYG-HDFL 457
            |:.:: |:...|:    .||...||.||.|||...| .|...|||...:.:.::|.|::. ||.:
Zfish   179 KVYLL-PDKKKKF----ETKVHRKTLNPVFNEQFTF-KVPYTELGGKTLVMTVYDFDRFSKHDAI 237

  Fly   458 GAAKVCLSTV---HSTSQYRISVPLGVEDQYSNAAEMAQNWPNGKMLLSLCYNTKRRALVVNVKQ 519
            |..||.::.|   |.|.::|        |..|  ||..:....|.:..||.|......|.|.|.:
Zfish   238 GDVKVPMNKVDFSHVTEEWR--------DLQS--AEKEEQEKLGDICFSLRYVPTAGKLTVVVLE 292

  Fly   520 CINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASPHDLNKEMLILT 584
            ..||..||..|.|||:|||.|..:..:.||.||::|..||||.|||.|.||.....:.|..:::|
Zfish   293 AKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVIT 357

  Fly   585 VWDKD-LGKSNDFLGSLQLGAQSKGERLQQWLDCIRLPDHFHEKWHCLAPD 634
            |.|.| :|| ||.:|.:.:|..|.|..|:.|.|.:..|.....:||.|.|:
Zfish   358 VLDYDKIGK-NDAIGKVFVGLNSTGTELRHWSDMLANPRRPIAQWHVLKPE 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	43/126 (34%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	52/132 (39%)
syt1a	NP_001314758.1	C2A_Synaptotagmin-1-5-6-9-10	139..261	CDD:176031	44/135 (33%)
syt1a	NP_001314758.1	C2B_Synaptotagmin-1	270..405	CDD:176047	53/135 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910