DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rph and syt5a

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_001096607.1	Gene:	syt5a / 436686	ZFINID:	ZDB-GENE-040718-110	Length:	405	Species:	Danio rerio

Alignment Length:	319	Identity:	98/319 - (30%)
Similarity:	151/319 - (47%)	Gaps:	35/319 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   320 DSSGSGSNNSGNSQTQSQYQQHQQQLQQHCRDPLLGWLEIAISYREAFHSLDCTMVRARDLPAMD 384
            :.:|......|..:.:.:|               .|.||..:.|....:.|...:::|:||||||
Zfish   106 EEAGEEQPKEGEGEGEKEY---------------YGKLEYTLDYNFTENQLIVGILQAQDLPAMD 155

  Fly   385 AAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDD 449
            ..|.:|||.|:.:: |:...|:    .||...|...|.||||..| .:...:|....:.:.:||.
Zfish   156 IGGTSDPYVKVYML-PDKKKKF----ETKVQRKNLCPVFNETFIF-KIPFNDLAGQTLVLQVFDF 214

  Fly   450 DKYG-HDFLGAAKVCLSTVHSTSQYRISVPLGVE-DQYSN--AAEMAQNWPNGKMLLSLCYNTKR 510
            |::| ||.:|..|:.::          |:.||.. .:|.:  ..|..:....|.:.:||.|....
Zfish   215 DRFGKHDVIGEIKIPMN----------SIDLGQPIHEYKDLVGGEKEEQEKLGDICISLRYVPTS 269

  Fly   511 RALVVNVKQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASPHD 575
            ..|.|.:.:..||..||..|.|||||||.|:.:..:.||.||:||..||||.:||.|.||.....
Zfish   270 GKLTVCIMEAKNLKKMDVGGLSDPFVKIVLQHNGKRIKKKKTTVKQNTLNPYFNESFSFEIPFAQ 334

  Fly   576 LNKEMLILTVWDKDLGKSNDFLGSLQLGAQSKGERLQQWLDCIRLPDHFHEKWHCLAPD 634
            :.|..:::||:|.|...|||.:|...:|..:.|..|:.|.|.:..|.....:||.|.|:
Zfish   335 IQKVQVLITVYDYDKLGSNDPIGKCWIGFGASGVGLRHWSDMLANPRRPVAQWHTLQPE 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	37/123 (30%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	50/131 (38%)
syt5a	NP_001096607.1	C2A_Synaptotagmin-1-5-6-9-10	128..246	CDD:176031	40/133 (30%)
syt5a	NP_001096607.1	C2B_Synaptotagmin-1	256..391	CDD:176047	51/134 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910