DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rph and syt11a

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_998625.2	Gene:	syt11a / 406769	ZFINID:	ZDB-GENE-040426-2815	Length:	451	Species:	Danio rerio

Alignment Length:	417	Identity:	118/417 - (28%)
Similarity:	181/417 - (43%)	Gaps:	62/417 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 MAKGIASTRLQREDSFRLRAYGSIRSFIDGGERKLSNSFFFNRQQSQRPSEC------PEYDS-- 294
            |.|||         |.......:.:..:..|.|..|||......:..|..:.      ||..:
Zfish    71 MLKGI---------SIYPETLSNSKKIVRVGRRSASNSLLREWGRGSRNGDVLLVDADPECGTTH 126

  Fly   295 VSMSKL-------RRESSFLRRGSVSSSWSISDSSGSGSNNSGNSQTQSQYQQHQQQLQQHCRDP 352
            :.|:.|       |.|    |...:.:.:...:|| |||::..:|:|.|.|.         ...|
Zfish   127 LQMNHLVPPVGPPRLE----RALPIRADYCCMESS-SGSSSEAHSKTASPYS---------LNSP 177

  Fly   353 LLGWLEIAISYREAFHSLDCTMVRARDLPAMD-AAGLADPYCKLNIITPEAHTKYTRWQRTKTVH 416
            .||.|.:||.|.....:|..|::.|:.|||:| .||.:|||.|:.|:..:.|.     .:|:.:.
Zfish   178 SLGTLSLAIDYNFPKKALVVTIIGAQGLPAVDEQAGSSDPYVKMTILPEKKHR-----VKTRVLR 237

  Fly   417 KTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYGH-DFLGAAKVCLSTVH-STSQYRISVPL 479
            ||..|.|:||..|.||....|....::..:...|::.. |.:|.|.|.|..|. ||.:..|:
Zfish   238 KTLEPVFDETFTFYGVPYSSLPELTLHFLVLSFDRFARDDVIGEAVVPLEGVDPSTGRAHIT--- 299

  Fly   480 GVEDQYSNAAEMAQNWPNGKMLLSLCYNTKRRALVVNVKQCINLMAMDNNG-SSDPFVKIQLKPD 543
               .|.|......::  .|::|:||.|:.....|.|.|.:..:|..||..| |.:|:||:.:...
Zfish   300 ---QQISKRNTQCES--RGELLVSLSYHPVTHRLNVVVLKAKHLPTMDITGLSGNPYVKVNVFYG 359

  Fly   544 AHKNKKHKTSVKWRTLNPIYNEEFYFEASPH---DLNKEMLILTVWDKDLGKSNDFLGSLQLGAQ 605
            ..:..|.||.||..||||::||.|.::....   |::.|.|::   |.|....|:.:|.|.||.|
Zfish   360 RKRIAKKKTHVKKCTLNPVFNESFIYDVPAELMPDISVEFLVI---DFDRTTKNEVVGRLVLGGQ 421

  Fly   606 SK-GERLQQWLDCIRLPDHFHEKWHCL 631
            |. ...:..|.:....|.....|||.|
Zfish   422 SPIPSGVTHWREVCDNPRRQIAKWHNL 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	42/125 (34%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	44/136 (32%)
syt11a	NP_998625.2	C2	179..290	CDD:301316	38/115 (33%)
syt11a	NP_998625.2	C2B_Synaptotagmin-4	312..449	CDD:176049	46/140 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910