Protein Alignment Rph and DH11.5

DIOPT Version :10

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: NP_001254131.1
• Gene: DH11.5 / 3565199
• WormBaseID: WBGene00008438
• Length: 825
• Species: Caenorhabditis elegans
• Alignment Length: 625
• Identity: 123/625 - (19%)
• Similarity: 206/625 - (32%)
• Gaps: 196/625 - (31%)

  Fly   164 RSASATPIPNPGPGSMAGDTRAVQSCHATPTRPARVKKLTIRVNDSSSSSSGH------------ 216
            :.|||:       |::..:....|||...   ..|.:|.....|||...|.||
 Worm   233 KDASAS-------GNVYNNGEYSQSCDLI---NGRSRKSPSTTNDSGRGSQGHLEEKMEAMVIEE 287

  Fly   217 -------SEPEDEVD----------------------TGVGIG----VGVVGGGMAKGIASTRLQ 248
                   .|.|:|:|                      |.:|:.    .....||....||.....
 Worm   288 HLENDCGCEEEEEIDAPILSSKRSGINRHRTSSCPDITSLGLNHPTTSAASSGGKKCPIAVDTDT 352

  Fly   249 REDSF-RLRAYGSIRSFIDG-GERKLSNSFFFNRQQ--------------------SQRPS---E 288
            .||:| |::...|..|..|. .||:|:..|...|:|                    |:|.:   :
 Worm   353 EEDNFERVKRPCSPISAADCLVERRLNRKFIEQRRQQVAMCHIDETCDVVSRISTTSRRTAQTED 417

  Fly   289 CPEYDS----------VSMSKLRRESS----FLRRGSVSSSWSISDSSGSGSNNSGNSQTQSQYQ 339
            ..::|.          :|.::|..:.|    |...|:....:  .:.:.|.||.:.:.||.....
 Worm   418 LADFDDNASSIILDHFLSTTELNFDDSDSADFSLNGACEDEF--DEPAPSSSNTATSVQTDLTLL 480

  Fly   340 QHQQQLQ---QHCRDPLLGWLEIAISY-------REAFHSLDCTMVRARDLPAMDAAGLADP--- 391
            ..:|::.   :||||..:...|..:::       .::|.::....|....:||..|.  .||
 Worm   481 NVEQEISEYLEHCRDASVNITEEGMNFIAKHFFEYQSFMNIPHKAVHLHKVPASQAG--TDPSMG 543

  Fly   392 YCKLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYG--- 453
            :...|::....| :.....|...||:...|...:..:....|..|.|           |::|
 Worm   544 WAPKNMLKAGKH-QPAPGARANRVHRDPRPNGTKYGRAGKHEHREWG-----------DRHGELR 596

  Fly   454 ----------------HDFLGA--AKVC------LSTVHSTSQYRI--SVPLGVEDQYSNAAEMA 492
                            :|..||  |..|      |:|...|.|.::  :.|   |....||...|
 Worm   597 DEKVACHKDAWTKFLANDDQGARTAFECDFEDRVLATEEETLQEKLCRTSP---EAMNLNALYAA 658

  Fly   493 QNWPNG------KMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQL----------K 541
            .|....      ::|..|.|....:.:...||:.   .|:..|.:  ||.:|.|          :
 Worm   659 ANKAVSCGGDVCELLTILTYAPTVQFVTTTVKKA---KALPYNNA--PFARIMLFEGRRLMEQKQ 718

  Fly   542 PDAHKNKKHKTSVKW-----------RTLNP---IYNEEFYFEASPHDLNKEMLILTVWDKDLGK 592
            ...:.:..||:||..           ...||   .::|.|.|...|..|::..:::.::|.|...
 Worm   719 TTVNPSLVHKSSVDGSKPSSSSASTSSNDNPSDVSFSESFLFHVPPTKLDRSHIVIELYDHDDEG 783

  Fly   593 SNDFLGSLQLGAQSKGERLQQWLDCIR---LPDHFHEKWH 629
            ....:|...:|....|.....|:..:|   ||...   ||
 Worm   784 GLQKIGHCVIGRLVDGTGNAHWIQMVRQHGLPVCM---WH 820

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710	3/7 (43%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	28/161 (17%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	33/158 (21%)
DH11.5	NP_001254131.1	C2B_Synaptotagmin	671..822	CDD:175975	33/158 (21%)