DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rph and Sytalpha

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_001188832.1	Gene:	Sytalpha / 35068	FlyBaseID:	FBgn0261089	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	438	Identity:	115/438 - (26%)
Similarity:	194/438 - (44%)	Gaps:	69/438 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 RVN--DSSSSSSGHSEPEDE-----VDTGVGIGV--------GVVGGGMAKGIASTRLQRED--- 251
            |:|  :.:...|.:.:.||:     |...||..|        |....|.|..::.|.|:.||
  Fly    52 RLNWFEQNLLESANEKDEDQQREALVAGAVGYNVDNVNEVPRGKYSSGNAGNLSPTSLKSEDNDP 116

  Fly   252 SFRLRAYGSIRSFIDGGERKLSNSFFFNRQQSQRP--------SECPEYDSVSMSKLRRESSFLR 308
            :|.:.|..:..:.|   ::::||:    .::|..|        |....|.|.:...:.|....:.
  Fly   117 AFWVPASVTSTAAI---QQQVSNT----TEESAPPTSPTGSLKSNTLSYCSTTSVPIARSDKHVV 174

  Fly   309 RGSVSSSWSISDSSGSGSNNSGNSQTQ---SQYQQHQQ--QLQQHCRDPLLGWLEIAISYREAFH 368
            .....|...:|      |.|:....|:   :.|:.|.|  .:.....:.:.|.|.:::.|.....
  Fly   175 LAMHPSRPRVS------SMNAKLDHTKIDMTLYRSHSQPKTINPVSLNEVRGNLHVSLGYDPVGG 233

  Fly   369 SLDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFV--- 430
            .|:..::.|::|.....:|.||||.|:.:: |:   |...|| |:...:|.||.|:|  |||
  Fly   234 LLNVRLLEAQNLQPRQFSGTADPYAKVRLL-PD---KKNFWQ-TRIHKRTLNPVFDE--QFVFEV 291

  Fly   431 --GVEPEELGNSLIYVALFDDDKYG-HDFLGAAKVCLSTVHSTSQYRISVPLGVEDQYSNAAEMA 492
              ||    :....:.:.|:|.|.|. |..:|.:|:.|:.:..:.|.::..||      |:|:...
  Fly   292 TAGV----IDKRTVEILLYDFDAYSRHVCIGGSKLHLANLDLSEQLKLWTPL------SSASAQD 346

  Fly   493 QNWPNGKMLLSLCYNTKRRALVVNVKQCINLMAMDN-NGSSDPFVKIQ-LKPDAHKNKKHKTSVK 555
            .....|.:::||.|......|:|.:.:..||..:|: ..||||:||:. |.|...|.||.||.|:
  Fly   347 MKVDLGDIMVSLAYLPSAERLMVVLIKARNLRIVDDARNSSDPYVKVTLLGPGGKKIKKRKTGVQ 411

  Fly   556 WRTLNPIYNEEFYFEASPHDLNKEMLILTVWDKDLGKSNDFLGSLQLG 603
            ..||||:|||...|:.:...|...:|..||....|..|::.||...:|
  Fly   412 RGTLNPVYNEALAFDVAKETLKNCVLEFTVVHDGLLGSSEILGRTLIG 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	36/128 (28%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	39/107 (36%)
Sytalpha	NP_001188832.1	C2A_Synaptotagmin-8	218..341	CDD:176033	38/139 (27%)
Sytalpha	NP_001188832.1	C2B_Synaptotagmin	352..488	CDD:175975	40/108 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468147
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
	4	3.840