Protein Alignment Rph and SYT10

DIOPT Version :9

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: NP_945343.1
• Gene: SYT10 / 341359
• HGNCID: 19266
• Length: 523
• Species: Homo sapiens
• Alignment Length: 530
• Identity: 129/530 - (24%)
• Similarity: 215/530 - (40%)
• Gaps: 140/530 - (26%)

  Fly   134 W-LCRICSETREMWKKSGAWFFKGLPKYDMPRSASATPIPNPGPGSMAGDTRAVQSCHATPTRPA 197
            | ||..|      ||..             |.:::.|.:|              ||..:.||...
Human    77 WKLCWPC------WKSK-------------PVTSNITTLP--------------QSISSAPTEVF 108

  Fly   198 RV-KKLTIRVNDSSSSSS-------GHSEPE--DEVDTGVGIGVGVVGGGMAKGIASTRLQRE-- 250
            .. :|..|:.|:..:..:       .|:.|:  .||.|.:...:          |...|:||:
Human   109 ETEEKKEIKENEKPAVKAIEPAIKISHTSPDIPAEVQTALKEHL----------IKHARVQRQIT 163

  Fly   251 ---DSFRLRAYGSIRSFIDGGERKLSNSFFFNRQQSQRPSECPEYDSVSMSKLRRESSFLRRGSV 312
               .|.|   :.|.|..:....:..|..|....:...:..|    .:.|:.:::.|  ..::.||
Human   164 EPTSSTR---HSSFRRHLPRQMQVSSVDFSMGTEPVLQRGE----TTTSIGRIKPE--LYKQKSV 219

  Fly   313 SSSWSISDSSGSGSNNSGNSQTQSQYQQHQQQLQQHCRDPLLGWLEIAISYREAFHSLDCTMVRA 377
                   ||.|                 :|.:..:.|     |.|...:.|......|...:::|
Human   220 -------DSEG-----------------NQNEDVKIC-----GKLNFTLQYDYENELLVVKIIKA 255

  Fly   378 RDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLI 442
            .||||.|..|.:|||.|:.:: |:...|:    :|:...||.||.|:||.|| .|..::|.|..:
Human   256 LDLPAKDFTGTSDPYVKMYLL-PDRKKKF----QTRVHRKTLNPLFDETFQF-PVAYDQLSNRKL 314

  Fly   443 YVALFDDDKYG-HDFLGAAKVCLSTVHSTSQYRISVPLGVEDQYSNAAEMAQNWPN--------- 497
            :.:::|.|::. ||.:|  :|.|..:.               :.|:.:..|..|.:
Human   315 HFSVYDFDRFSRHDMIG--EVILDNLF---------------EVSDLSREATVWKDIHCATTESI 362

  Fly   498 --GKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLN 560
              |:::.||||......:.:.|.:|.||.|||..|||||:||:.|..:..:.||.||:.|..|||
Human   363 DLGEIMFSLCYLPTAGRMTLTVIKCRNLKAMDITGSSDPYVKVSLMCEGRRLKKRKTTTKKNTLN 427

  Fly   561 PIYNEEFYFEASPHDLNKEMLILTVWDKDLGKSNDFLGSLQLGAQSKGERLQQWLDCIRLPDHFH 625
            |:|||...|:..|.::::..|.:.|.|.|....|:.:|..:.|..::|.....|.:.:.    :|
Human   428 PVYNEAIIFDIPPENVDQVSLSIAVMDYDRVGHNEVIGVCRTGLDAEGLGRDHWNEMLA----YH 488

  Fly   626 EK----WHCL 631
            .|    ||.|
Human   489 RKPITHWHPL 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600	8/38 (21%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	37/123 (30%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	46/135 (34%)
SYT10	NP_945343.1	Cysteine motif. /evidence=ECO:0000250|UniProtKB:O35681	13..35
		C2A_Synaptotagmin-1-5-6-9-10	232..356	CDD:176031	41/151 (27%)
		C2B_Synaptotagmin-3-5-6-9-10	365..498	CDD:176048	47/136 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910