DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rph and btsz

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_001247109.1	Gene:	btsz / 3346167	FlyBaseID:	FBgn0266756	Length:	3734	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	130/523 - (24%)
Similarity:	217/523 - (41%)	Gaps:	106/523 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 GLPKYDMPRSASATPIPNPGPGSMA-----GDTRAVQSCHATPTRPARVKKLTIRVNDSSSSSSG 215
            |.|....|::.|.:.: |..|.:::     |..::.:  :.:|...||    ...|:.:...|||
  Fly  3218 GAPITSTPKTKSQSAL-NHTPSNLSTVSATGSAKSAR--YRSPGLAAR----AAAVSGAGGGSSG 3275

  Fly   216 HSEPEDEVDTGVGIGVGVVGGGMAKGI------------ASTRLQRE-DSFRLRAYGSIRSFIDG 267
                        |:|||...|...|.:            |..||... :..::.|....||.:.
  Fly  3276 ------------GVGVGASSGSTGKKLGAGFQFLYSKRDARKRLNMSAEEAKVAAEELSRSPVI- 3327

  Fly   268 GERKL--SNSFFFNRQQSQR-PSECPEYDSVSMSKLRRESSFLRRGSVSSSWSISDSSGSGSNNS 329
            |:|:.  |.|...:|..|:. |::..| |...:..:.:..|.|....|.|....|..||:|....
  Fly  3328 GQRQADGSGSPIQSRASSETWPTQSDE-DIDRLVAMHQNRSSLSSLGVRSESMASVYSGAGEGRY 3391

  Fly   330 GNSQTQSQYQQHQQQLQQHCRDPLLGWLEIAISYREAFHSLDCTMVRARDLPAMDA-AGLADPYC 393
            |....:.|                   :|.|:.|.....:|:..:||.:||.|:|| ...:|||.
  Fly  3392 GTVVVKGQ-------------------VEFAMQYNYKLSALEVHVVRCKDLAAVDAKRNRSDPYV 3437

  Fly   394 KLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYG-HDFL 457
            |:.:: |:......|  :||....|.||.|:||::| ......|.:..:::.::..|.:| :|||
  Fly  3438 KVYLL-PDKSKAGKR--KTKVKKHTLNPIFDETMRF-HTPISSLESRTLWLTVWHSDMFGRNDFL 3498

  Fly   458 GAAKVCL-------------------STVHSTSQYRISVPLGVE---------DQYSNAAEMAQN 494
            |...|.|                   ......:.||..:.:|::         ..:|..:.:..:
  Fly  3499 GEVSVNLQGRLFDNPQSQWYLLQERSEPFDEVATYRGDIVVGLKYIPPENIKSSFFSRGSSITGS 3563

  Fly   495 WPN----GKMLLSLCYNTKRRA----LVVNVKQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHK 551
            ..|    |..:.|:...::|.:    |.|.||:..:|..:..||:.|.|.|..|.||..::.|.|
  Fly  3564 SSNLRKFGGSIKSVASKSERTSKGGQLHVLVKEAKHLSPIKANGTCDAFCKSYLLPDRTRSSKQK 3628

  Fly   552 TSVKWRTLNPIYNEEFYFE-ASPHDLNKEMLILTVWDKDLGKSNDFLGSLQ--LGAQSKGERLQQ 613
            |.|..|||:|.:|..|.:| .|..:|::..|.|||||.|...||:|:|.::  ||......|..:
  Fly  3629 TPVVKRTLHPSWNYTFVYEDVSLEELSERALELTVWDHDRLASNEFVGGIRFSLGTGRSYGRQVE 3693

  Fly   614 WLD 616
            |:|
  Fly  3694 WMD 3696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600	4/15 (27%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	37/143 (26%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	44/125 (35%)
btsz	NP_001247109.1	FYVE_Slp3_4_5	26..73	CDD:277286
		SOBP	<300..476	CDD:291927
		C2A_SLP	3398..3520	CDD:176056	36/144 (25%)
		C2B_SLP_1-2-3-4	3534..3723	CDD:175987	49/163 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I3424
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm1065
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910