Protein Alignment Rph and PsGEF

DIOPT Version :10

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: XP_061507031.1
• Gene: PsGEF / 3289835
• VectorBaseID: AGAMI1_000312
• Length: 2142
• Species: Anopheles gambiae
• Alignment Length: 637
• Identity: 119/637 - (18%)
• Similarity: 205/637 - (32%)
• Gaps: 192/637 - (30%)

  Fly   140 SETREMWKKSGAWFFKGLPKYDMPRSA-SATPIPNPG------PGSMA-----GDTRAVQSCHAT 192
            |..::..:..|.........||..... ::||.||.|      |.|||     ..|.:...|..:
Mosquito    58 SRNKKARRSFGGVIHVACTNYDKENQCITSTPHPNIGRAASGSPYSMALRDVSNITPSTTPCRQS 122

  Fly   193 PTRPARVKKLTIRVNDSSSSSSGHSEPEDEVDTGV-----------GIGVGVVGGGMAKGIASTR 246
            .|.|.. :|..:.|:..|:|.:...:.|:..:|..           ..||..:.....:|:|||.
Mosquito   123 NTTPLG-RKRALPVSPVSASFNQKEQIENIRETYATTLPSFDIEYSPCGVKNIPFLALRGLASTE 186

  Fly   247 LQREDSF-----------RLRAY-----------------------------GSIRSFIDGGER- 270
            ..:...:           :::|:                             ..||.......|
Mosquito   187 FDKPGRYFSADEKAPTPKKIKAFVKPMLVDNFSTEFVEDNLNPCVTPLSSKMSEIRCSKTNYNRT 251

  Fly   271 -----KLSNSFFFNRQQSQRPSECPEYDSVSMSKLRRESS-------------FLRRGSVSSSWS 317
                 |.:|.|.........||. .:.|::..::|...||             .|......:.|:
Mosquito   252 FSTVNKTANVFLLPSAPLIAPSS-SDIDNIENTELSLNSSEMGDLTLDKMIDAILESAKKENHWT 315

  Fly   318 ISDSSGSGSNNSGNSQTQSQYQQHQQQLQQHCRDPLLG-WLEIAISYREAFHSLDCTMVRARDLP 381
            ....:.|.|..|..|:..|       .......||... :||.::..:...|..:.||:. .:..
Mosquito   316 TQRPNRSLSVKSKLSKLSS-------PTYTPADDPAADLYLEQSLPLQMLRHDRETTMIN-EETS 372

  Fly   382 AMDAAGLADPYCK--------LNI----ITPEAHTKYTR---------WQRTKTVHKTRNPEF-- 423
            .::...:..|..|        :||    .|.::.||:.|         .:|.|.|.:....|.
Mosquito   373 KLNEREVKTPDIKHEKLCSTVINISKADYTRQSITKHIRASPLETACHLRRQKAVRRKHKLEAAN 437

  Fly   424 NETLQFVGVEPEELGNSLI------YVALFDDDKY----------GHDFLG-------------- 458
            |:.:.:...:...|.|:.|      |:.. ...|:          .:|:.|
Mosquito   438 NDAILYANTDEYRLDNNQITSPETPYIPC-SQSKFIQINEMQTPNRNDYQGQEQENPPTQFKLSD 501

  Fly   459 -----------------------AAKVCLS---TVHSTS-QYRISVPLGVEDQYSNAAEMAQNWP 496
                                   .::.||.   |:...| ..|.||......:||.|:.:.....
Mosquito   502 NATPDIRPIDLQGTSTPTGGSIEISRKCLDFSPTLGDNSIDKRRSVASTTSSRYSRASTLTGACS 566

  Fly   497 -NGKMLLSLCYNTKRRALVVNVKQCINLM------AMDNNGSSDPFVKIQLKPDAHKNKK----- 549
             .|.:.||:.....|| |.|:|.:|.:|.      :...|...:.:||:.|......|:.
Mosquito   567 VRGTLELSIYLEPDRR-LHVHVIRCKDLQRNCFPGSTATNNVINAYVKVALIHIGDTNQTTEKEL 630

  Fly   550 --HKTSVKWRTLNPIYNEEFYFEASPHDLNKEMLILTVWDKDLG-KSNDFLG 598
              .:|:|...:.||.|::.|.||..|:|  :..:.|.||.:|.. |.::|||
Mosquito   631 GFQRTTVHRNSNNPYYDQRFIFEIYPND--ERRIQLAVWHRDREIKRSEFLG 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710	6/32 (19%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	30/203 (15%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	32/114 (28%)
PsGEF	XP_061507031.1	None