Protein Alignment Rph and Sytl5

DIOPT Version :10

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: NP_848016.2
• Gene: Sytl5 / 302538
• RGDID: 631342
• Length: 753
• Species: Rattus norvegicus
• Alignment Length: 764
• Identity: 177/764 - (23%)
• Similarity: 286/764 - (37%)
• Gaps: 192/764 - (25%)

  Fly    34 SKTSE-----PLRPEEQEAIISVIRRNEEIEVAERQRVGRLVERVEKIKQHA---VERGPNCCRL 90
            ||.||     .|...|:|.|:.|::|:|.::..|.:|:.:|...:.:.|:.:   .:.....|..
  Rat     2 SKNSEFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTHQEANRVCVH 66

  Fly    91 CGDTFGILRPQRILCEDCRQSVCTKCSV---DINIRYHTSERSREIWLCRICSETREMWKKSGAW 152
            |..:.|::..:...|:.|...||::|.|   |.:            |.|.:|::..::...||.|
  Rat    67 CQKSLGLIFDRGDPCQACSLRVCSECRVTGLDGS------------WKCTVCAKVAQLRIISGEW 119

  Fly   153 FFKGLPK---------------YDMPRSASATPIPN---PGPGSMAGDTRAVQSCHATPTRPARV 199
            |.:...|               ..:.||..:..|.|   ...|:...||.:.....||...|.|.
  Rat   120 FLEEKAKRFKQVNVLGTDVVRQSILRRSPGSEEIQNQEQAHQGADKSDTLSSVRQKATHDGPKRK 184

  Fly   200 KKLTIRVNDS-------------------------------SSSSSGHSEPEDEVDTGVGIGV-- 231
            ..|..:...:                               |.|..|.:...|.:|...|.|.
  Rat   185 GFLLSKFRSATRGEIKTPKAESGRSYSLDLDNQNLQSFKSVSGSDRGSTTSSDLIDQEAGRGAPK 249

  Fly   232 GVVGGGMAKGIASTRLQREDSFRLRAYGSIRSFIDGGERKLSNSFF----------FNRQQSQRP 286
            |....|   ||..|  ||..:...|:..||.|...|.|..::.:..          ..|..|..|
  Rat   250 GSCSNG---GIPVT--QRSPAPSARSVTSISSREHGFENSMALATIESISEELTKSHRRNTSGTP 309

  Fly   287 SECPEYDSVSMSKLRRE-------------SSFLRRGSVSSSW-----SISD------------S 321
            |......|:|..:.|.|             :|.:|..||..:.     |:.|            |
  Rat   310 SIAVSGTSLSSERSRSELDLSESFAEDLEDTSSIRSRSVPGALDKDLNSLEDTEDGVDLVSSRFS 374

  Fly   322 SGSGSNNSGNSQTQSQYQQHQQQLQQHCRD------------------------PLLGWLEIAIS 362
            :.:.|..||.| |.||....:::...|..|                        .:.|.:.:.||
  Rat   375 ANTHSLASGLS-TSSQAGSDRKRSYLHVPDADSDTTSLNSMMSVYSETGDYGNVKVTGEILLHIS 438

  Fly   363 YREAFHSLDCTMVRARDLPAMD-AAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKT-RNPEFNE 425
            |......|...:...|:|...| .....|.|.| :.:.|:.    ||..:.||..:| .||||||
  Rat   439 YCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVK-SYLLPDK----TRNNKRKTKIRTGTNPEFNE 498

  Fly   426 TLQFVGVEPEELGNSLIYVALFDDDKYG-HDFLGAAKVCLSTVHSTS--------QYRISVPLGV 481
            ||::. :...:|....:.::::..|::| :.|||..::...:.:..:        |.::.:...:
  Rat   499 TLKYT-ISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIAFDSWNFENPCDEWFVLQPKVELAPDI 562

  Fly   482 EDQYSNAAEMAQNW-------------PNGKMLLSLCYNTKRRA-----LVVNVKQCINLMAMDN 528
            ..||.....:...:             |.||.:.......:..|     |.|.:|:..||.|:..
  Rat   563 SLQYKGELTIVLRYIPPEENLIFPVEQPQGKKIFKKGKKKESPAISGGILEVFIKEAKNLTAVKA 627

  Fly   529 NGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEA-SPHDLNKEMLILTVWDKDLGK 592
            .|:||.|||..|.||.:|..||||:|..:::||.:|..|.|.. .|.|:....|.||:|||:...
  Rat   628 GGTSDSFVKGYLLPDDNKATKHKTAVVKKSVNPQWNHVFIFSGLYPQDIQNACLELTIWDKEAFS 692

  Fly   593 SNDFLGSLQLGAQ---SKGERLQQWLDCIRLPDHFHEK--WHCLAPDNP 636
            ||.|||.::|.:.   |.|:.: .|:|     ....|:  |..:| |||
  Rat   693 SNIFLGGVRLNSGSGISHGKAV-DWMD-----SRGEEQRLWQKMA-DNP 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710	20/105 (19%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	32/133 (24%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	48/142 (34%)
Sytl5	NP_848016.2	PHD_SF	11..123	CDD:473978	28/123 (23%)
		FYVE_Slp5	62..108	CDD:277305	13/57 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..188		11/42 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	221..283		19/66 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	298..359		12/60 (20%)
		C2A_SLP-4_5	430..553	CDD:175995	31/128 (24%)
		C2B_SLP_1-2-3-4	567..745	CDD:175987	54/175 (31%)