DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rph and Doc2g

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	XP_006230797.1	Gene:	Doc2g / 293654	RGDID:	1307473	Length:	389	Species:	Rattus norvegicus

Alignment Length:	300	Identity:	102/300 - (34%)
Similarity:	159/300 - (53%)	Gaps:	25/300 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   354 LGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKT 418
            ||.||..:.:.....:|.||..||:.|.. .|.|..|.|.|.|:: |.|........||:||..|
  Rat    84 LGTLEFTLLFDVDNSTLHCTAHRAKGLKP-PATGSVDTYVKANLL-PGASKVRASQLRTRTVRGT 146

  Fly   419 RNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYGH----DFLGAAKV---------------CL 464
            |.|.:.|||.:.|...::.|...:.:.:.:|.:...    ..||..:|               ||
  Rat   147 REPVWEETLTYHGFTCQDAGRKTLRLCVCEDSRLRRRRRAPPLGELRVPLRKLVPNRARSFDICL 211

  Fly   465 STVHSTSQYR-ISVPLGVE--DQYSNAAEMAQNWPNGKMLLSLCYNTKRRALVVNVKQCINLMAM 526
            .....|.:.: :....|:.  ::....||:.:. ..|::||||||:::|..|:|.|.:|.:|..|
  Rat   212 EKRRLTKRPKSLDTARGMSLYEEEEVEAEVFRE-ERGRILLSLCYSSERGGLLVGVLRCAHLAPM 275

  Fly   527 DNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASPHDLNKEMLILTVWDKDLG 591
            |.||.|||||::.|.|.:.|..|:||||:.:||||.:||||::.....:|.::.|:::|||.|||
  Rat   276 DANGYSDPFVRLFLHPSSGKKSKYKTSVRRKTLNPEFNEEFFYAGLREELAQKALLVSVWDYDLG 340

  Fly   592 KSNDFLGSLQLGAQSKGERLQQWLDCIRLPDHFHEKWHCL 631
            .::||:|.:||..:|.|:||:.|.:|:...|...|.||.|
  Rat   341 TADDFIGGVQLSGRSSGDRLRHWCECLSHCDRRLELWHLL 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	37/142 (26%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	60/131 (46%)
Doc2g	XP_006230797.1	C2A_Rabphilin_Doc2	84..211	CDD:176000	34/128 (27%)
Doc2g	XP_006230797.1	C2	248..380	CDD:301316	60/131 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	127	1.000	Domainoid score	I5232
eggNOG	1	0.900	-	-		E1_KOG1013
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185575at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	1	1.000	-	-		otm44766
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45729
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.880