Protein Alignment Rph and Sytl4

DIOPT Version :10

• Sequence 1: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: NP_038785.1
• Gene: Sytl4 / 27359
• MGIID: 1351606
• Length: 673
• Species: Mus musculus
• Alignment Length: 683
• Identity: 163/683 - (23%)
• Similarity: 264/683 - (38%)
• Gaps: 170/683 - (24%)

  Fly    44 EQEAIISVIRRNEEIEVAERQRVGRLVERVEKIKQHAVERG-----PNCCRLCGDTFGILRPQRI 103
            |::.|:.|::|:||:..|:.:|:.||...:.:||:...:||     ...|..|.:..|.|.|:..
Mouse    14 ERDLILGVLQRDEELRKADEKRIRRLKNELLEIKRKGAKRGSQHYSDRTCARCQEGLGRLIPKSS 78

  Fly   104 LCEDCRQSVCTKCSVDINIRYHTSERSREIWLCRICSETREMWKKSGAWFF-------------- 154
            .|..|...||.:|.|         ..|...|.|::||:..|:.|.:|.||:
Mouse    79 TCVGCNHLVCRECRV---------LESNGSWRCKVCSKEIELKKATGDWFYDQKVNRFDYRTGSE 134

  Fly   155 ------KGLPKYDMPRSASATPIPNPGPGSMAGDTRAVQS---------CHATPTR------PAR 198
                  :..|..:...:|..:.:.....|.:....|.:|.         .....||      .|.
Mouse   135 IIRMSLRQKPAVNKRETAGQSLLQQTQMGDIWPGRRIIQEQQQREQSVLFEVPKTRSGKSALEAE 199

  Fly   199 VKKLTIRVNDSSSSS-------SG-------HSEPEDEVDTGV--GIGVGVVG--GGMAKGIAST 245
            .:.|.....||.|:|       ||       .|.|:.:|:..:  |....|.|  |.|.
Mouse   200 SESLDSYTADSDSTSRRDSLDKSGLFPEWKKMSAPKSQVEKEIPPGNQNAVCGDEGDMV------ 258

  Fly   246 RLQREDSFRLRAYGSIRSFID-------------GGERKLSNSFFFNRQQSQRPSECPEYDSVSM 297
             .::.....||.....:|.||             |...|.......:.::.:...|    |...:
Mouse   259 -FKKNTKKVLRPSEYTKSVIDLRPEDVAQESGILGDRSKSVPGLSVDMEEEEEEEE----DIDHL 318

  Fly   298 SKLRRESSFLRRGSVSSSWSIS---------DSSGSGSNNS--GNSQTQSQYQQHQQQLQQHCRD 351
            .||.|:.  |.|||:.|..|:|         ..:|...|.|  |......:::|..|.|
Mouse   319 VKLHRQK--LARGSMQSGSSMSTLGSIMSIYSEAGDFGNISVTGKIAFSLKFEQKTQTL------ 375

  Fly   352 PLLGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKTVH 416
                          ..|..:|..:...|    :|...::||.|..:: |:...:..|  :|....
Mouse   376 --------------VIHVKECHQLAYAD----EAKKRSNPYVKTYLL-PDKSRQGKR--KTSIKR 419

  Fly   417 KTRNPEFNETLQFVGVEPEELGNSL-----IYVALFDDDKYGHD-FLGAAKVCLSTVHSTSQYRI 475
            .|.||.::||.::      |:..||     :..:::...::|.: |||.|:|.:.:.....:...
Mouse   420 DTINPLYDETFRY------EISESLLAQRTLQFSVWHHGRFGRNTFLGEAEVHMDSWKLDKKLDH 478

  Fly   476 SVPLGVEDQYSNAAEMAQNWP--NGKMLLSLCY---------NTKRRA-------LVVNVKQCIN 522
            .:||    ....:.|.:...|  .|::::||.|         ..::::       |.|.:|:..|
Mouse   479 CLPL----HGKISTESSPGLPAHKGELVVSLKYIPASKLPVGGDRKKSKGGEGGELQVWIKEAKN 539

  Fly   523 LMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEF-YFEASPHDLNKEMLILTVW 586
            |.|..:.|:||.|||..|.|..:|..|.||.|..:||:|.||..| |......||....|.||||
Mouse   540 LTAAKSGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLSPHYNHTFVYNGVRLEDLQHMCLELTVW 604

  Fly   587 DKDLGKSNDFLGSLQLGAQ---SKGERLQQWLD 616
            |::...||||||.::||..   |.|| :..|:|
Mouse   605 DREPLASNDFLGGVRLGVGTGISNGE-VVDWMD 636

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710	24/112 (21%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	24/128 (19%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	50/138 (36%)
Sytl4	NP_038785.1	PHD_SF	8..121	CDD:473978	35/115 (30%)
		FYVE_Slp4	58..107	CDD:277303	15/57 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	184..253		15/68 (22%)
		C2A_SLP-4_5	359..483	CDD:175995	30/160 (19%)
		C2B_SLP_1-2-3-4	498..663	CDD:175987	51/140 (36%)