DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rph and Syt3

DIOPT Version :9

Sequence 1:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_061995.1	Gene:	Syt3 / 25731	RGDID:	3805	Length:	588	Species:	Rattus norvegicus

Alignment Length:	487	Identity:	121/487 - (24%)
Similarity:	195/487 - (40%)	Gaps:	95/487 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 PGSMAGD--------------TRAVQSCHATPTRPARVKKLTIRVNDSSSSSSGHSEPEDEVDTG 226
            ||.:.|.              ..||.|..|...:|::                  :.||...:.|
  Rat   149 PGGLGGSEPPEPSYLDMDSYPEAAVASVVAAGVKPSQ------------------TSPELPSEGG 195

  Fly   227 VGIGVGVV---GGGMAKGIASTRLQREDSFRLRAYGSIRSFIDGGERKLSNSFFFNR---QQSQR 285
            .|.|:.::   |||:..  |.:..|.........|.::       .|.|:......:   ...:|
  Rat   196 TGSGLLLLPPSGGGLPS--AQSHQQVTSLAPTTRYPAL-------PRPLTQQTLTTQADPSSEER 251

  Fly   286 PSECP------EYDSVSMSKLRRESSFLRRGSVSSSWSISDSSGSGSNNSGNSQTQSQYQQHQQQ 344
            |...|      |..:..:.:::.|              :...:|.|...:|....::
  Rat   252 PPALPLPLPGGEEKAKLIGQIKPE--------------LYQGTGPGGRRTGGGSGEA-------- 294

  Fly   345 LQQHCRDPLLGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRW 409
             ...|     |.:..|:.|......|...:::|.||||.|:.|.:|||.|:.:: |:...|:
  Rat   295 -GAPC-----GRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLL-PDRKKKF--- 349

  Fly   410 QRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYG-HDFLGAAKVCLSTVHSTSQY 473
             :||...||.||.||||.|| .|...||....::.:::|.|::. ||.:|  :|.|..:...::.
  Rat   350 -QTKVHRKTLNPIFNETFQF-SVPLAELAQRKLHFSVYDFDRFSRHDLIG--QVVLDNLLELAEQ 410

  Fly   474 RISVPLGVEDQYSNAAEMAQNWPNGKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKI 538
            ....||. .|.....:|.|.   .|::..||||......|.|.:.:..||.|||..|.|||:||.
  Rat   411 PPDRPLW-RDILEGGSEKAD---LGELNFSLCYLPTAGLLTVTIIKASNLKAMDLTGFSDPYVKA 471

  Fly   539 QLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASPHDLNKEMLILTVWDKDLGKSNDFLGSLQLG 603
            .|..:..:.||.|||:|..||||.|||...|:.:|..:....|.:.|.|.|....|:.:|..::|
  Rat   472 SLISEGRRLKKRKTSIKKNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVG 536

  Fly   604 AQSKGER-LQQWLDCIRLPDHFHEKWHCLAPD 634
            .::.... .:.|.:.:..|....|.||.|..:
  Rat   537 PEAADPHGREHWAEMLANPRKPVEHWHQLVEE 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	39/123 (32%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	45/132 (34%)
Syt3	NP_061995.1	Cysteine motif. /evidence=ECO:0000250\|UniProtKB:O35681	10..34
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	129..161		3/11 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	183..222		11/58 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	238..257		2/18 (11%)
		C2A_Synaptotagmin-1-5-6-9-10	297..422	CDD:176031	43/138 (31%)
		C2B_Synaptotagmin-3-5-6-9-10	431..565	CDD:176048	46/133 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910